Chromosome 1p: Loss of Heterozygosity (LOH)
Notes
**Note 1:** This SSDI is effective for diagnosis years 2023+.
* For cases diagnosed 2018-2022, leave this SSDI blank
**Note 2:** Physician statement of Chromosome 1p deletion/LOH can be used to code this data item.
**Note 3:** This is a special molecular diagnostic test performed on tumor tissue to identify loss of genetic material normally found on the short arm of one of the patient's two copies of chromosome 1. A normal cell will contain two complete copies of each chromosome, one from each parent, and this normal state is termed heterozygous. Loss of heterozygosity (LOH) is an abnormal state reflecting loss of the whole arm of chromosome 1p following a chromosomal translocation event.
**Note 4:** Other terms for LOH include whole arm loss, gene deletion and allelic loss.
Metadata
SSDI
| Code |
Description |
| 0 |
Chromosome 1p deletion/LOH not identified/not present |
| 1 |
Chromosome 1p deletion/LOH identified/present |
| 7 |
Test ordered, results not in chart |
| 8 |
Not applicable: Information not collected for this case
(If this information is required by your standard setter, use of code 8 may result in an edit error.) |
| 9 |
Not documented in medical record
Cannot be determined by pathologist
Chromosome 1p deletion/LOH not assessed or unknown if assessed |
| <BLANK> |
N/A - Diagnosis year is prior to 2023 |
