Clinical N

This input is used for staging

Notes

**Note 1:** Only peripheral lymph nodes are assessed which include the cervical, supraclavicular, epitrochlear, axillary, and inguinal nodal groups. * Clinically abnormal peripheral lymph node(s) is defined as any palpable peripheral node that on physical examination is firm, irregular, clustered, fixed, or 1.5 centimeter (cm) or larger in diameter * Central nodes, which are not generally amenable to pathologic assessment, are not currently classified in the nodal classification unless used to establish N3 histopathologically **Note 2:** Dutch grade system includes Grade 1 - Dermatopathic lymphadenopathy (DL) Grade 2 - Early involvement by mycosis fungoides (MF), (presence of cerebriform nuclei larger than 7.5 micrometers (um) Grade 3 - Partial effacement of lymph node architecture; many atypical cerebriform mononuclear cells (CMCs) Grade 4 - Complete effacement of lymph node architecture **Note 3:** National Cancer Institute - Lymph Nodes (NCI LN) grade system includes LN0 - No atypical lymphocytes LN1 - Occasional and isolated atypical lymphocytes not arranged in clusters LN2 - Many atypical lymphocytes or in 3-6 cell clusters LN3 - Aggregates of atypical lymphocytes; nodal architecture preserved LN4 - Partial/complete effacement of nodal architecture by atypical lymphocytes or frankly neoplastic cells **Note 4:** A T-cell clone (clone negative or clone positive) is defined by polymerase chain reaction (PCR) or Southern blot analysis of the T-cell receptor gene. **Note 5:** For this site, code all lymph node(s) (regional and distant) involvement in this field.

NAACCR Item

NAACCR #950
Clinical N Clinical N Display Description Registrar Notes
cX cNX Clinically abnormal peripheral lymph nodes; no histologic confirmation Clinical classification criteria met, evaluation done:
Physician unable to assess N
Regional lymph node involvement cannot be determined or findings inconclusive
Physician assigns cNX, no other information available to determine N
c0 cN0 No clinically abnormal peripheral lymph nodes; biopsy not required No regional lymph node involvement

Clinically enlarged palpable lymph node(s) (adenopathy) WITH pathologically negative nodes
c1 cN1 Clinically abnormal peripheral lymph nodes; histolopathology Dutch grade1 or NCI LN0-2 Note: N1 has subcategories of N1a and N1b. Assign N1 only when there is no information available to assign one of the subcategories

Clinically abnormal or normal peripheral lymph node(s)
AND histopathologically Dutch grade 1 or unknown OR NCI LN0-2 or unknown
Clone unknown

Regional lymph nodes, NOS
Lymph nodes, NOS

Stated as N1 [NOS]
c1A cN1a Clone negative Clinically abnormal or normal peripheral lymph node(s)
AND histopathologically Dutch grade 1 or NCI LN0-2:
Clone negative

Stated as N1a
c1B cN1b Clone positive Clinically abnormal or normal peripheral lymph node(s)
AND histopathologically Dutch grade 1 or NCI LN0-2:
Clone positive

Stated as N1b
c2 cN2 Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3 Note: N2 has subcategories of N2a and N2b. Assign N2 only when there is no information available to assign one of the subcategories

Clinically abnormal or normal peripheral lymph node(s)
AND histopathologically Dutch grade 2 or NCI LN3:
Clone unknown

Stated as N2 [NOS]
c2A cN2a Clone negative Clinically abnormal or normal peripheral lymph node(s)
AND histopathologically Dutch grade 2 or NCI LN3:
Clone negative

Stated as N2a
c2B cN2b Clone positive Clinically abnormal or normal peripheral lymph node(s)
AND histopathologically Dutch grade 2 or NCI LN3:
Clone positive

Stated as N2b
c3 cN3 Clinically abnormal peripheral lymph nodes; histolopathology Dutch grades 3-4 or NCI LN4; clone positive or negative Clinically abnormal or normal peripheral lymph nodes
AND histopathologically Dutch grades 3-4 or NCI LN4:
Clone positive or negative or unknown

Stated as N3
88 88 Not applicable In situ case but no pTis is defined by EORTC
Death certificate only (DCO) case
<BLANK> BLANK See Registrar Notes Clinical classification criteria not met
Clinical classification criteria met, evaluation done:
No information about diagnostic workup
Results not documented in record
Tumor first detected on surgical resection (no clinical workup)
Evidence of metastatic disease [(cM1) or (pM1)], no other workup
Only Clinical Stage Group documented (no T, N, or M information available)