Clinical T

This input is used for staging


**Note 1:** Impaired vocal cord mobility, also described as vocal cord paresis, may suggest invasion of intrinsic laryngeal muscle. Fixation of the vocal cord may be described as immobility of the arytenoids noted on endoscopy, vocal cord paralysis, or deviation of larynx to fixed side. **Note 2:** Assign T1 for localized tumor only if no information is available to identify further extension.


Clinical T Clinical T Display Description Registrar Notes
cX cTX Primary tumor cannot be assessed Clinical classification criteria met, evaluation done:
Physician unable to assess T
Extension cannot be determined
Physician assigns cTX, no other information available to determine T
c0 cT0 No evidence of primary tumor
pIS pTis Carcinoma in situ Intraepithelial, noninvasive

Stated as Tis
c1 cT1 Tumor limited to subglottis Invasive tumor with normal vocal cord mobility confined to subglottis

Localized, NOS

Stated as T1
c2 cT2 Tumor extends to vocal cord(s)
WITH normal or impaired mobility
Tumor involves adjacent regions(s) of larynx:
WITH normal or impaired mobility

Stated as T2
c3 cT3 Tumor limited to larynx
WITH vocal cord fixation
Stated as T3
c4 cT4 Not defined by UICC*# Note: T4 has subcategories of T4a and T4b. Assign T4 only when there is no information available to assign one of the subcategories

Tumor invades bone, nerve or extrinsic deep muscles

Stated as T4[NOS]
c4A cT4a Tumor invades cricoid or thyroid cartilage and/or invades tissues beyond the larynx, e.g.,
Soft tissues of neck including deep/extrinsic muscle of tongue
Strap muscles
Base of tongue
Hypopharynx, NOS
Postcricoid area
Pre-epiglottic tissues
Pyriform sinus (pyriform fossa)

Extension to/through:
Cervical esophagus
Deep extrinsic muscles of tongue
Strap muscles:
Soft tissues of neck
Thyroid gland

Stated as T4a
c4B cT4b Tumor invades:
Prevertebral space
Encases carotid artery
Mediastinal structures
Stated as T4b
88 88 Not applicable Primary site/histology not TNM defined
Death certificate only (DCO) case
<BLANK> BLANK See Registrar Notes Clinical classification criteria not met
Clinical classification criteria met, evaluation done:
No information about diagnostic workup
Results not documented in record
Clinical evaluation of primary tumor not done or unknown if done
Tumor first detected on surgical resection (no clinical workup)
Evidence of metastatic disease [(cM1) or (pM1)], no other workup
Only Clinical Stage Group documented (no T, N, or M information available)
\* T4 [NOS] is not defined by UICC in the 7th edition. Approval has been provided by UICC to use "Tumor invades bone, nerve or extrinsic deep muscles" as T4 [NOS]. \# T4 [NOS] is not defined in AJCC 7th edition.