BRAF Mutational Analysis
Notes
**Note 1:** This SSDI is effective for diagnosis years 2024+ * For cases diagnosed 2018-2023, leave this SSDI blank **Note 2:** Physician statement of BRAF can be used to code this data item when no other information is available. **Note 3:** BRAF is a gene which belongs to a class of genes known as oncogenes. When mutated, oncogenes have the potential to cause normal cells to become cancerous. Studies suggest that BRAF gene mutations are often present in Astrocytoma. The most common BRAF mutations are * BRAF V600E (c.1799T>A) mutation * *KIAA1549: BRAF* gene fusion **Note 4:** The most common testing methods for BRAF are * Direct Sanger sequencing * High-resolution melting analysis * Pyrosequencing * Real-time PCR **Note 5:** If BRAF is positive and there is no mention of the mutated codon, or the mutated codon is not specified, code 4. **Note 6:** If neoadjuvant therapy is given, record the assay from tumor specimens prior to neoadjuvant therapy. * If neoadjuvant therapy is given and there are no BRAF results from pre-treatment specimens, report the findings from post-treatment specimensNAACCR Item
NAACCR #3940Metadata
SSDI| Code | Description |
|---|---|
| 0 | Normal BRAF negative, BRAF wild type Negative for (somatic) mutations, no alterations, no (somatic) mutations identified, not present, not detected |
| 1 | Abnormal (mutated)/detected: BRAF V600E (c.1799T>A) mutation |
| 2 | Abnormal (mutated)/detected, but not BRAF V600E (c.1799T>A) mutation |
| 3 | Abnormal (mutated)/detected, *KIAA1549: BRAF* gene fusion |
| 4 | Abnormal (mutated) BRAF, NOS |
| 7 | Test ordered, results not in chart |
| 8 | Not applicable: Information not collected for this case (If this information is required by your standard setter, use of code 8 may result in an edit error.) |
| 9 | Not documented in medical record Cannot be determined by pathologist BRAF not assessed or unknown if assessed |
| <BLANK> | N/A-Diagnosis is prior to 2024 |