NAACCR Item #3939: EGFR Mutational Analysis

Item # Length Source of Standard Year Implemented Version Implemented Year Retired Version Retired
3,939 1 NAACCR 2021 21

NAACCR XML: Tumor.egfrMutationalAnalysis


Epidermal growth factor receptor (EGFR) mutational analysis is performed for patients with advanced non-small cell lung cancer (NSCLC) to identify patients with certain activating mutations in the EGFR gene which are sensitive to tyrosine kinase inhibitors.


EGFR mutational analysis is recommended by treatment guidelines for patients with advanced lung cancer as a prognostic marker and factor in determining appropriate therapy. It is a new data item for cases diagnosed 01/01/2021+.


0Normal EGFR negative, EGFR wild type Negative for mutations, no alterations, no mutations (somatic) identified, not present, not detected
1Abnormal (mutated)/detected in exon(s) 18, 19, 20, and/or 21
2Abnormal (mutated)/detected but not in exon(s) 18, 19, 20, and/or 21
4Abnormal (mutated)/detected, NOS, exon(s) not specified
7Test ordered, results not in chart
8Not applicable: Information not collected for this case If this information is required by your standard setter, use of code 8 may result in an edit error.
9Not documented in medical record EGFR not assessed or unknown if assessed
BlankDiagnosis year is prior to 2021

Each Site-Specific Data Item (SSDI) applies only to selected primary sites, histologies, and years of diagnosis. Depending on applicability and standard-setter requirements, SSDIs may be left blank.