EOD Regional Nodes
Notes
**Note 1:** All lymph node (regional and distant) involvement is coded in this field. * Peripheral nodes (e.g., palpable/accessible nodes) may be used to code this. * Central nodes (code 700) (deep/non-palpable nodes) are only included when they are microscopically proven **Note 2:** Regional node involvement (clinical abnormal peripheral lymph nodes) can be clinically involved despite negative biopsy or a lack of microscopic confirmation. **Note 3:** Dutch grade system includes - Grade 1 - Dermatopathic lymphadenopathy (DL) - Grade 2 - Early involvement by mycosis fungoides (MF), (presence of cerebriform nuclei larger than 7.5 micrometers (um)) - Grade 3 - Partial effacement of lymph node architecture; many atypical cerebriform mononuclear cells (CMCs) - Grade 4 - Complete effacement of lymph node architecture **Note 4:** National Cancer Institute - Lymph Nodes (NCI LN) grade system includes - LN 0 - No atypical lymphocytes - LN 1 - Occasional and isolated atypical lymphocytes not arranged in clusters - LN 2 - Many atypical lymphocytes or in 3-6 cell clusters - LN 3 - Aggregates of atypical lymphocytes; nodal architecture preserved - LN 4 - Partial/complete effacement of nodal architecture by atypical lymphocytes or frankly neoplastic cells **Note 5:** A T-cell clone (clone negative or clone positive) is defined by polymerase chain reaction (PCR) or Southern blot analysis of the T-cell receptor gene (TCR).| Code | Description | SS2018 N |
|---|---|---|
| 000 | No regional lymph node involvement No clinically abnormal peripheral lymph nodes, no biopsy required | NONE |
| 050 | Clinically enlarged palpable peripheral lymph node(s) (adenopathy) - WITH pathologically negative nodes OR - WITHOUT histologic confirmation | RN |
| 100 | Clinically abnormal peripheral lymph nodes - Pathologically Dutch grade 1 or NCI LN 0-2 - Clone negative | RN |
| 200 | Clinically abnormal peripheral lymph nodes - Pathologically Dutch grade 1 or NCI LN 0-2 - Clone positive | RN |
| 300 | Clinically abnormal peripheral lymph nodes - Pathologically Dutch grade 1 or NCI LN 0-2 - Clone unknown OR Dutch grade and NCI LN grade unknown - Clone positive, negative, or unknown | RN |
| 400 | Clinically abnormal peripheral lymph nodes - Pathologically Dutch grade 2 or NCI LN 3 - Clone negative | RN |
| 500 | Clinically abnormal peripheral lymph nodes - Pathologically Dutch grade 2 or NCI LN 3 - Clone positive | RN |
| 600 | Clinically abnormal peripheral lymph nodes - Pathologically Dutch grade 2 or NCI LN 3 - Clone unknown | RN |
| 700 | Clinically abnormal peripheral lymph nodes - Pathologically Dutch grades 3-4 or NCI LN 4 - Clone positive or negative or unknown Central nodes - Pathologically Dutch grades 3-4 or NCI LN 4 - Clone positive, negative, or unknown | RN |
| 800 | Regional lymph node(s), NOS Lymph node(s), NOS Distant lymph node(s), NOS | RN |
| 999 | Unknown; regional lymph node(s) not stated Regional lymph node(s) cannot be assessed Not documented in medical record Death Certificate Only | U |