Brain
| Primary Site | Histology | Behavior | 
|---|---|---|
| C700, C710-C719 | 8000-8700, 8720-8790, 8802, 8810, 8815, 8850, 8890, 8900, 9064, 9070-9071, 9080, 9084-9085, 9100-9105, 9120, 9133, 9140, 9180, 9220, 9362, 9364, 9380-9540, 9680, 9699, 9702-9715, 9751-9759 | 3 | 
| C700, C710-C719 | 8000-9993 | 0, 1 | 
Notes
**Malignant histologies (/3):** 8000-8700, 8720-8790, 8802, 8810, 8815, 8850, 8890, 8900, 9064, 9070-9071, 9080, 9084-9085, 9100-9105, 9120, 9133, 9140, 9180, 9220, 9362, 9364, 9380-9540, 9680, 9699, 9702-9715, 9751-9759 **Benign/Borderline histologies (/0, /1):** All histologies (8000-9993) C700 Cerebral meninges C710 Cerebrum C711 Frontal lobe C712 Temporal lobe C713 Parietal lobe C714 Occipital lobe C715 Ventricle, NOS C716 Cerebellum, NOS C717 Brain stem C718 Overlapping lesion of brain C719 Brain, NOS **Note 1:** The following sources were used in the development of this schema * SEER Extent of Disease 1988: Codes and Coding Instructions (3rd Edition, 1998) (https://seer.cancer.gov/archive/manuals/EOD10Dig.3rd.pdf) * SEER Summary Staging Manual-2000: Codes and Coding Instructions (https://seer.cancer.gov/tools/ssm/ssm2000/) * Collaborative Stage Data Collection System, version 02.05: https://cancerstaging.org/cstage/Pages/default.aspx * Chapter 72 *Brain and Spinal Cord*, in the AJCC Cancer Staging Manual, Eighth Edition (2017) published by Springer International Publishing. Used with permission of the American College of Surgeons, Chicago, Illinois. **Note 2:** While all histologies with behavior /0 and /1 are captured in this schema, for behavior /3, see the following schemas for the listed histologies * 8710-8714, 8800-8801, 8803, 8811-8814, 8816-8818, 8820-8842, 8851-8858, 8860-8881, 8891-8898, 8902-8905, 8921, 8932-8934, 8940-8990, 9000-9016, 9030-9043, 9045-9063, 9065, 9072-9073, 9081-9083, 9086-9091, 9110-9111, 9121-9132, 9135-9138, 9141-9175, 9181-9213, 9221, 9230, 9240-9361, 9363, 9365, 9370-9373, 9541-9580, 9582: *Soft Tissue Other* * 8804-8806, 8859, 8901, 8910-8920, 8930-8931, 8991, 9020, 9044, 9222, 9231, 9366-9368, 9581: *Soft Tissue Rare* * 8935-8936: *GIST* * 9700-9701: *Mycosis Fungoides* **Note 3:** Summary Stage is the only applicable staging system for this site/histology/schema.Data Items
| Name | Default Value | Used in Derivation | NAACCR Item | Required By | Metadata | 
|---|---|---|---|---|---|
| Year of Diagnosis | No | NAACCR #390 dateOfDiagnosis | None | ||
| Primary Site | Yes | NAACCR #400 primarySite | None | ||
| Histology | Yes | NAACCR #522 histologicTypeIcdO3 | None | ||
| Behavior | Yes | NAACCR #523 behaviorCodeIcdO3 | None | ||
| Tumor Size Clinical | No | NAACCR #752 tumorSizeClinical | None | ||
| Tumor Size Pathological | No | NAACCR #754 tumorSizePathologic | None | ||
| Tumor Size Summary | 999 | No | NAACCR #756 tumorSizeSummary | None | |
| Regional Nodes Positive | 99 | No | NAACCR #820 regionalNodesPositive | None | |
| Regional Nodes Examined | 99 | No | NAACCR #830 regionalNodesExamined | None | |
| LVI | 8 | No | NAACCR #1182 lymphVascularInvasion | None | |
| EOD Primary Tumor | 999 | Yes | NAACCR #772 eodPrimaryTumor | None | |
| EOD Regional Nodes | 888 | Yes | NAACCR #774 eodRegionalNodes | None | |
| EOD Mets | 00 | Yes | NAACCR #776 eodMets | None | |
| SS2018 | No | NAACCR #764 summaryStage2018 | None | ||
| Grade Clinical | 9 | No | NAACCR #3843 gradeClinical | CCCR/Canada COC NPCR SEER | SSDI | 
| Grade Pathological | 9 | No | NAACCR #3844 gradePathological | CCCR/Canada COC NPCR SEER | SSDI | 
| Grade Post Therapy Clin (yc) | No | NAACCR #1068 gradePostTherapyClin | COC NPCR SEER | SSDI | |
| Grade Post Therapy Path (yp) | No | NAACCR #3845 gradePostTherapy | CCCR/Canada COC NPCR SEER | SSDI | |
| Brain Molecular Markers | 88 | No | NAACCR #3816 brainMolecularMarkers | NPCR SEER | SSDI | 
| Chromosome 1p Status | 8 | No | NAACCR #3801 chromosome1pLossHeterozygosity | COC SEER | SSDI | 
| Chromosome 19q Status | 8 | No | NAACCR #3802 chromosome19qLossHeterozygosity | COC SEER | SSDI | 
| MGMT | 8 | No | NAACCR #3889 methylationOfO6MGMT | COC SEER | SSDI | 
Initial Context
Outputs
| Name | Default Value | Description | NAACCR Item | Metadata | 
|---|---|---|---|---|
| Schema ID | 00721 | NAACCR #3800 schemaId | None | |
| Derived Version | {{ctx_alg_version}} | None | None | |
| Derived Summary Stage 2018 | 9 | NAACCR #762 derivedSummaryStage2018 | None |