NAACCR Item #3889: Methylation of O6-Methylguanine-Methyltransferase

Item # Length Source of Standard Year Implemented Version Implemented Year Retired Version Retired
3,889 1 NAACCR

NAACCR XML: Tumor.methylationOfO6MGMT


O6-Methylguanine-Methyltransferase (MGMT) is an enzyme in cells that repairs DNA. Methylation of the MGMT gene reduces production of MGMT enzyme and the ability of tumor cells to repair damage caused by chemotherapy. Methylation of MGMT is a prognostic and predictive factor for high grade gliomas.


Methylation of O6-Methylguanine-Methyltransferase (MGMT) is a Registry Data Collection Variable in AJCC. It was previously collected as Brain, CS SSF #4.


0MGMT methylation absent/not present, unmethylated MGMT
1MGMT methylation present, low level Hypomethylated Partial methylated
2MGMT methylation present, high level Hypermethylated
3MGMT Methylation present, level unspecified
6Benign or borderline tumor
7Test ordered, results not in chart
8Not applicable: Information not collected for this case (If this item is required by your standard setter, use of code 8 will result in an edit error.)
9Not documented in patient record Cannot be determined by the pathologist MGMT not assessed or unknown if assessed

Each Site-Specific Data Item (SSDI) applies only to selected primary sites, histologies, and years of diagnosis. Depending on applicability and standard-setter requirements, SSDIs may be left blank.