Brain Molecular Markers

Notes

**Note 1:** This data item was introduced in 2018 and applied to the following ICD-O-3 histology codes 9400/3, 9401/3, 9440/3, 9450/3, 9451/3, 9471/3, 9478/3 * These are codes 01-09 and are applicable for cases diagnosed 2018+ and are in ICD-O-3 order **Note 2:** In 2022, the 5th edition of the CNS WHO Blue Book was released and the following histologies were added 9385/3, 9396/3, 9421/1, 9430/3, 9500/3 * These are codes 10-23 and are applicable for cases diagnosed 2024+ and are in ICD-O-3 order **Note 3:** If a microscopically confirmed histology is not included in this list, assign, code 85. * If your case is not microscopically confirmed, code 99 **Note 4:** Physician statement of histologic subtype can be used to code this data item. **Note 5:** See Brain Molecular Markers in the SSDI Manual, in the *Definition* section for more information on the different histologies. ***Examples:*** 1. Biopsy of brain tumor, microscopic confirmation diagnosis: Diffuse Astrocytoma (9400/3). Additional testing done, and IDH-mutant is identified. Code 01. 2. Biopsy of brain tumor, microscopic confirmation diagnosis: Anaplastic astrocytoma (9401/3). No further testing or results unknown. Code 99. 3. MRI of brain tumor, clinical diagnosis: glioblastoma. No further workup. Code 99. 4. Biopsy of brain tumor, microscopic confirmation diagnosis: Mixed glioma (9382/3). Code 85.

Default

88

NAACCR Item

NAACCR #3816

Metadata

SSDI
Code ICD-O-3 Code ICD-O-Description
01 9400/3 Astrocytoma, IDH-mutant, grade 2
02 9400/3 Diffuse astrocytoma, IDH-wildtype
03 9401/3 Astrocytoma, IDH-mutant, grade 3
04 9401/3 Anaplastic astrocytoma, IDH-wildtype
05 9440/3 Glioblastoma, IDH-wildtype
06 9450/3 Oligodendroglioma, IDH-mutant and 1 p/19q co-deleted
07 9451/3 Oligodendroglioma, IDH-mutant and 1p/19q co-deleted, grade 3
08 9471/3 Medulloblastoma, SHH-activated and TP53-wildtype
09 9478/3 Embryonal tumor with multilayered rosettes, C19MC-altered
10 9385/3 Diffuse hemispheric glioma, H3-34 mutant
11 9385/3 Diffuse midline glioma, H3 K27-altered
12 9385/3 Diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype
13 9385/3 Infant-type hemispheric glioma
14 9396/3 Posterior fossa group A (PFA) ependymoma
15 9396/3 Posterior fossa group B (PFB) ependymoma
16 9396/3 Spinal ependymoma, MYCN-amplified
17 9396/3 Supratentorial ependymoma, YAP1 fusion-positive
18 9396/3 Supratentorial ependymoma, ZFTA fusion-positive
19 9421/1 Diffuse astrocytoma, MYB- or MYBL1-altered
20 9421/1 Diffuse low-grade glioma, MAPK pathway-altered
21 9430/3 Astroblastoma, MN1-altered
22 9500/3 CNS neuroblastoma, FOXR2-activated
23 9500/3 CNS tumor BCOR internal tandem duplication
85 NA Not applicable: Histology not 9385/3, 9396/3, 9400/3, 9401/3, 9430/3, 9440/3, 9450/3, 9451/3, 9471/3, 9478/3, 9421/1, 9430/3, 9500/3
86 NA Benign or borderline tumor Excludes: 9421/1 (codes 19-20)
87 NA Test ordered, results not in chart
88 NA Not applicable: Information not collected for this case (If this item is required by your standard setter, use of code 88 will result in an edit error.)
99 NA Not documented in medical record No microscopic confirmation Brain molecular markers not assessed or unknown if assessed