EGFR Mutational Analysis
Notes
**Note 1:** This SSDI is effective for diagnosis years 2021+ * For cases diagnosed 2018-2020, leave this SSDI blank **Note 2:** Physician statement of EGFR can be used to code this data item when no other information is available. **Note 3:** EGFR may be recorded for all histologies and stages; however, it is primarily performed for advanced non-small cell carcinomas. If information is not available, code 9. **Note 4:** The most common EGFR mutations are * Exon 18 Gly719 * Exon 19 deletion * Exon 20 insertion * Exon 20 Thr790Met * Exon 21 Leu858Arg **Note 5:** If EGFR is positive and there is no mention of the mutated codon, or the mutated codon is not specified, code 4. **Note 6:** If neoadjuvant therapy is given, record the assay from tumor specimens prior to neoadjuvant therapy. * If neoadjuvant therapy is given and there are no EGFR results from pre-treatment specimens, report the findings from post-treatment specimens **Note 7:** Code 9 when * Insufficient amount of tissue available to perform test * No microscopic confirmation of tumor * EGFR not ordered or not done, or unknown if ordered or doneDefault
8NAACCR Item
NAACCR #3939Metadata
SSDI 2021–| Code | Description |
|---|---|
| 0 | Normal EGFR negative, EGFR wild type Negative for mutations, no alterations, no mutations (somatic) identified, not present, not detected |
| 1 | Abnormal (mutated)/detected in exon(s) 18, 19, 20, and/or 21 |
| 2 | Abnormal (mutated)/detected but not in exon(s) 18, 19, 20, and/or 21 |
| 4 | Abnormal (mutated)/detected, NOS, exon(s) not specified |
| 7 | Test ordered, results not in chart |
| 8 | Not applicable: Information not collected for this case (If this information is required by your standard setter, use of code 8 may result in an edit error.) |
| 9 | Not documented in medical record EGFR not assessed or unknown if assessed |
| <BLANK> | N/A - Diagnosis year is prior to 2021 |