Human Papilloma Virus (HPV) Status

Notes

**Note 1:** There is evidence that human papilloma virus (HPV) plays a role in the pathogenesis of some cancers. HPV testing may be performed for prognostic purposes; testing may also be performed on metastatic sites to aid in determination of the primary site. **Note 2:** Record the results of any HPV testing performed on pathological specimens including surgical and cytological (from cell blocks) tissue from the primary tumor or a metastatic site, including lymph nodes. Do not record the results of blood tests or serology. **Note 3:** There are several methods for determination of HPV status. The most frequently used test is IHC for p16 expression which is surrogate marker for HPV infection. **Do not record the results of IHC p16 expression in this field.** The rest of the tests (based on ISH, PCR, RT-PCR technologies) detect the viral DNA or RNA. **This data item is only for HPV status determined by tests designed to detect viral DNA or RNA.** **Note 4:** HPV-type 16 refers to virus type and is different from p16 overexpression (p16+). **Note 5:** Codes 0-7 are hierarchical; use the highest code that applies.

Default

99

NAACCR Item

NAACCR #3700

Metadata

None
Code Description
10 HPV negative by p16 test
11 HPV positive by p16 test
20 HPV negative for viral DNA by ISH test
21 HPV positive for viral DNA by ISH test
30 HPV negative for viral DNA by PCR test
31 HPV positive for viral DNA by PCR test
40 HPV negative by ISH E6/E7 RNA test
41 HPV positive by ISH E6/E7 RNA test
50 HPV negative by RT-PCR E6/E7 RNA test
51 HPV positive by RT-PCR E6/E7 RNA test
70 HPV status reported in medical records as negative, but test type is unknown
71 HPV status reported in medical records as positive, but test type is unknown
97 Test done, results not in chart
99 Not documented in medical record HPV test not done, not assessed, or unknown if assessed