Grade Post Therapy Path (yp)
Notes
**Note 1:** Leave Grade Post Therapy Path (yp) blank when
* No neoadjuvant therapy
* Clinical or pathological case only
* Neoadjuvant therapy completed; surgical resection not done
* There is only one grade available and it cannot be determined if it is clinical, pathological, post therapy clinical or post therapy pathological
**Note 2:** Assign the highest grade from the resected primary tumor assessed after the completion of neoadjuvant therapy.
**Note 3:** If there are multiple tumors with different grades abstracted as one primary, code the highest grade.
**Note 4:** Codes 1-4 take priority over A-D, L and H.
**Note 5:** CNS WHO classifications use a grading scheme that is a "malignancy scale" ranging across a wide variety of neoplasms rather than a strict histologic grading system that can be applied equally to all tumor types.
* Code the WHO grading system for selected tumors of the CNS as noted in the AJCC 8th edition Table 72.2 when WHO grade is not documented in the record
+ A list of the histologies that have a default grade can also be found in the *Brain/Spinal Cord* CAP Protocol in Table 1: *WHO Grading System for Some of the More Common Tumors of the CNS*, Table 2: *WHO Grading System for Diffuse Infiltrating Astrocytomas and Table* 3: *WHO Grading Meningiomas*
https://www.cap.org/protocols-and-guidelines/cancer-reporting-tools/cancer-protocol-templates
* For **benign tumors ONLY (behavior 0),** code 1 can be automatically assigned for all histologies
+ This was confirmed by the CAP Cancer Committee
**Note 6:** Use the grade from the post therapy **clinical work up** from the primary tumor in different scenarios based on behavior or surgical resection
* **Behavior**
* Tumor behavior for the post therapy clinical and the post therapy pathological diagnoses are the same AND the post therapy clinical grade is the highest grade
* Tumor behavior for post therapy clinical diagnosis is invasive, and the tumor behavior for the post therapy pathological diagnosis is in situ
* **Surgical Resection**
* Surgical resection is done of the primary tumor after neoadjuvant therapy is completed and there is no grade documented from the surgical resection
* Surgical resection is done of the primary tumor after neoadjuvant therapy is completed and there is no residual cancer
**Note 7:** Code 9 (unknown) when
* Surgical resection is done after neoadjuvant therapy and grade from the primary site is not documented and there is no grade from the post therapy clinical work up
* Surgical resection is done after neoadjuvant therapy and there is no residual cancer and there is no grade from the post therapy clinical work up
* Grade checked "not applicable" on CAP Protocol (if available) and no other grade information is available
Metadata
SSDI
| Code |
Description |
| 1 |
WHO Grade I : Circumscribed tumors of low proliferative potential associated with the possibility of cure following resection |
| 2 |
WHO Grade II: Infiltrative tumors with low proliferative potential with increased risk of recurrence |
| 3 |
WHO Grade III: Tumors with histologic evidence of malignancy, including nuclear atypia and mitotic activity, associated with an aggressive clinical course |
| 4 |
WHO Grade IV: Tumors that are cytologically malignant, mitotically active, and associated with rapid clinical progression and potential for dissemination |
| L |
Stated as "low grade" NOS |
| H |
Stated as "high grade" NOS |
| A |
Well differentiated |
| B |
Moderately differentiated |
| C |
Poorly differentiated |
| D |
Undifferentiated, anaplastic |
| 9 |
Grade cannot be assessed (GX); Unknown |
| <BLANK> |
See Note 1 |
