Brain Molecular Markers
Notes
**Note 1:** This data item applies only to ICD-O-3 histology codes: 9400/3, 9401/3, 9440/3, 9450/3, 9451/3, 9471/3 and 9478/3. If a microscopically confirmed histology is not included in this list, assign code 85.
* If your case is not microscopically confirmed, code 99
**Note 2:** Physician statement of histologic subtype can be used to code this data item.
**Note 3:** Only one code is applicable for each tumor.
* IDH mutation status distinguishes between clinically important subtypes within ICD-O-3 9400/3, Diffuse astrocytoma and 9401/3, Anaplastic astrocytoma.
* IDH mutant and 1p/19q co-deletion distinguishes between clinically important subtypes within ICD-O-3 code 9450/3, Oligodendroglioma and 9451/3, Anaplastic Oligodendroglioma.
* IDH-wildtype distinguishes clinically important subtypes within ICD-O-3 9400/3, Diffuse astrocytoma, 9401/3, Anaplastic astrocytoma and 9440/3, Glioblastoma, Epithelioid glioblastoma and Glioblastoma, NOS (note that the new ICD-O-3 code 9445/3 applies to Glioblastoma, IDH-mutant; information regarding this subtype is not collected using this data item).
* SHH-activation and TP53-wildtype distinguishes between clinically important subtypes within ICD-O-3 histology code 9471/3, Medulloblastoma.
* C19MC alteration status distinguishes a clinically important highly aggressive subtype within ICD-O-3 9478/3, Embryonal tumor with multilayered rosettes.
***Examples:***
1. Biopsy of brain tumor, microscopic confirmation diagnosis: Diffuse Astrocytoma (9400/3). Additional testing done, and IDH-mutant is identified. Code 01.
2. Biopsy of brain tumor, microscopic confirmation diagnosis: Anaplastic astrocytoma (9401/3). No further testing or results unknown. Code 99.
3. MRI of brain tumor, clinical diagnosis: glioblastoma. No further workup. Code 99.
4. Biopsy of brain tumor, microscopic confirmation diagnosis: Mixed glioma (9382/3). Code 85.
Default
88
Metadata
SSDI
| Code |
Description |
| 01 |
Diffuse astrocytoma, IDH-mutant (9400/3) |
| 02 |
Diffuse astrocytoma, IDH-wildtype (9400/3) |
| 03 |
Anaplastic astrocytoma, IDH-mutant (9401/3) |
| 04 |
Anaplastic astrocytoma, IDH-wildtype (9401/3) |
| 05 |
Glioblastoma, IDH-wildtype (9440/3) |
| 06 |
Oligodendroglioma, IDH-mutant and 1 p/19q co-deleted (9450/3) |
| 07 |
Anaplastic oligodendroglioma, IDH-mutant and 1p/19q co-deleted (9451/3) |
| 08 |
Medulloblastoma, SHH-activated and TP53-wildtype (9471/3) |
| 09 |
Embryonal tumor with multilayered rosettes, C19MC-altered (9478/3) |
| 85 |
Not applicable: Histology not 9400/3, 9401/3, 9440/3, 9450/3, 9451/3, 9471/3, 9478/3 |
| 86 |
Benign or borderline tumor |
| 87 |
Test ordered, results not in chart |
| 88 |
Not applicable: Information not collected for this case
(If this item is required by your standard setter, use of code 88 will result in an edit error.) |
| 99 |
Not documented in medical record
No microscopic confirmation
Brain molecular markers not assessed or unknown if assessed |
