CS Site-Specific Factor 1
Estrogen Receptor (ER) Assay
Notes
**Note 1**: * A. In cases where ER is reported on more than one tumor specimen (except as noted in B, D, and E), record the highest value. If any sample is positive, record as positive. * B. If neoadjuvant therapy is given, record the assay from tumor specimens prior to neoadjuvant therapy. * C. If neoadjuvant therapy is given and there are no ER results from pre-treatment specimens, report the findings from post-treatment specimens. * D. If the patient is ER positive and node negative, a multigene test such as OncotypeDX may be performed, in which case another ER test will be performed. Do not record the results of that test in this field. Record only the results of the test which made the patient eligible to be given the multigene test. * E. If ER is positive on an in situ specimen and ER is negative on all tested invasive specimens, code ER as negative (code 020). **Note 2**: In general, estrogen receptor (ER) assay is only performed on one sample. In cases where the assay is performed on more than one sample, there is not necessarily any reason to think that the most accurate is the test done on the "largest" tumor specimen. Clinically, treatment will be based on any positive test; with the benefit and minimal toxicity of hormonal therapy, most patients will be given the "benefit of the doubt" and treated with hormonal therapy if any ER test is positive. See exception in Note 1E. **Note 3**: The most recent interpretation guidelines for ER do not allow for a borderline result. Therefore, code 030 will rarely be used. If 1% or greater cells stain positive, the test results are considered positive. If less than 1% of cells stain positive, the results are considered negative.Default
999NAACCR Item
NAACCR #2880Metadata
CCCR_III_COLLECTED_IN_CSV1COC_ALREADY_COLLECTED
NPCR_REQUIRED_BY_NPCR_2010_FORWARD
SEER_ALREADY_COLLECTED
| Code | Description |
|---|---|
| 000 | OBSOLETE DATA CONVERTED V0203 See code 998 Test not done (test not ordered and not performed) |
| 010 | Positive/elevated |
| 020 | Negative/normal; within normal limits |
| 030 | Borderline; undetermined whether positive or negative |
| 080 | OBSOLETE DATA CONVERTED V0203 See code 997 Ordered, but results not in chart |
| 988 | Not applicable: Information not collected for this case (If this item is required by your standard setter, use of code 988 will result in an edit error.) |
| 996 | Test ordered, results not interpretable |
| 997 | Test ordered, results not in chart |
| 998 | Test not done (test not ordered and not performed) |
| 999 | Unknown or no information Not documented in patient record |