Liver

Primary Site Histology Staging Type
C220 8000-8157, 8162-8169, 8190-9136, 9141-9582, 9700-9701 Summary Stage only
C220 8170-8175 TNM 7 and Summary Stage
C221 8170-8175 Summary Stage only

If you are working with a site/histology that only summary stages and you need to directly code it, please use the SEER Summary Stage 2000 manual

Notes

C220 Liver C221 Intrahepatic bile duct **Note 1:** This schema is based on the UICC chapter *Liver-Hepatocellular Carcinoma* pages 110-113. * Primary site C221 with histologies 8170-8175 is not listed in this chapter of the UICC manual; however, it is included in this schema, but is not TNM staged **Note 2:** For primary site C220 and cholangiocarcinoma histologies (M-8160, 8161, and 8180), see the Bile DuctsIntraHepat schema. **Note 3:** Although the presence of cirrhosis is an important prognostic factor, it does not affect the TNM classification, being an independent prognostic variable. **Note 4:** In addition to directly assigning TNM, Summary Stage 2000 (SS2000) must be captured. If directly assigning SS2000, use the *Liver and Intrahepatic Bile Ducts* chapter on page 108 of the [SS2000 on-line manual](https://seer.cancer.gov/tools/ssm/ssm2000/SSSM2000-122012.pdf#page=108).

Main Data Items

Name Default Value Used for Staging NAACCR Item Required By Metadata
Clinical T <BLANK> Yes NAACCR #940
tnmClinT 		None
Clinical N <BLANK> Yes NAACCR #950
tnmClinN 		None
Clinical M <BLANK> Yes NAACCR #960
tnmClinM 		None
TNM Clin Stage Group 99 Yes NAACCR #970
tnmClinStageGroup 		None
Pathologic T <BLANK> Yes NAACCR #880
tnmPathT 		None
Pathologic N <BLANK> Yes NAACCR #890
tnmPathN 		None
Pathologic M <BLANK> Yes NAACCR #900
tnmPathM 		None
TNM Path Stage Group 99 Yes NAACCR #910
tnmPathStageGroup 		None
SSF1: Alpha Fetoprotein (AFP) Interpretation 999 No NAACCR #2880
csSiteSpecificFactor1 		CCCR/Canada
COC
SEER		 None
SSF2: Fibrosis Score 988 No NAACCR #2890
csSiteSpecificFactor2 		CCCR/Canada
COC		 None
SSF3: Alpha Fetoprotein (AFP) Lab Value 988 No NAACCR #2900
csSiteSpecificFactor3 		CCCR/Canada
COC		 None
SSF4: Creatinine Value 988 No NAACCR #2910
csSiteSpecificFactor4 		CCCR/Canada
COC		 None
SSF5: Creatinine Unit of Measure 988 No NAACCR #2920
csSiteSpecificFactor5 		CCCR/Canada
COC		 None
SSF6: Total Bilirubin Value 988 No NAACCR #2930
csSiteSpecificFactor6 		CCCR/Canada
COC		 None
SSF7: Total Bilirubin Unit of Measure 988 No NAACCR #2861
csSiteSpecificFactor7 		CCCR/Canada
COC		 None
SSF8: International Normalized Ratio for Prothrombin Time (INR) 988 No NAACCR #2862
csSiteSpecificFactor8 		CCCR/Canada
COC		 None

Additional Data Items

Name Default Value Used for Staging NAACCR Item Required By Metadata
Year of Diagnosis <BLANK> No NAACCR #390
dateOfDiagnosis 		None
Primary Site <BLANK> Yes NAACCR #400
primarySite 		None
Histology <BLANK> Yes NAACCR #522
histologicTypeIcdO3 		None
RX Summ Systemic/Surgery Sequence <BLANK> Yes NAACCR #1639
rxSummSystemicSurSeq 		None
RX Summ Surgery/Radiation Sequence <BLANK> Yes NAACCR #1380
rxSummSurgRadSeq 		None
Regional Nodes Positive <BLANK> Yes NAACCR #820
regionalNodesPositive 		None

Initial Context

Staging Methods

Expand All | Collapse All

TNM 7 Stage

Inclusion Table

Primary Site Histology
C220 8170-8175

Start

Additional Context
Pathologic Stage Group = 90
Clinical Stage Group = 90

Next Step

  2. Parse T
  3. clin_t_prefix
    tmp_clin_t

Next Step

  2. Parse N
  3. clin_n_prefix
    tmp_clin_n

Next Step

  2. Parse M
  3. tmp_clin_m
    clin_m_prefix

Next Step

  2. Parse T
  3. tmp_path_t
    path_t_prefix

Next Step

  2. Parse N
  3. tmp_path_n
    path_n_prefix

Next Step

  2. Parse M
  3. tmp_path_m
    path_m_prefix

Next Step

  2. Determine Default T
  3. Source T
    tmp_path_t
    tmp_clin_t
    tmp_combined_t

Next Step

  2. Determine Default N
  3. tmp_combined_n
    tmp_clin_n
    tmp_path_n
    Source N

Next Step

  2. Determine Default M
  3. tmp_path_m
    tmp_combined_m
    tmp_clin_m
    Source M

Next Step

  2. TNM 7 Stage Group
  3. Clinical Stage Group

Next Step

  2. TNM 7 Path Stage Group
  3. Pathologic Stage Group

Next Step

  2. Adjustments for No Clin or No Path
  3. tmp_combined_n
    tmp_combined_m
    Source T
    Clinical Stage Group
    Pathologic Stage Group
    Source N
    tmp_combined_t
    Source M

End

Combined Stage

Inclusion Table

Primary Site Histology
C220 8170-8175

Start

Additional Context
Combined Stage Group = 90
Combined N = 90
Combined M = 90
Combined T = 90

Next Step

  2. Stop if No Clin and No Path
  3. Combined M
    Combined N
    Source T
    tmp_continue
    Combined T
    Combined Stage Group
    Source N
    Source M

Next Step

  2. Combined T No Tis
  3. Source T
    tmp_combined_t

Next Step

  2. Combined N
  3. tmp_combined_n
    Source N

Next Step

  2. Combined M
  3. tmp_combined_m
    tmp_source_m
    Source M

Next Step

  2. Determine Combined Prefix
  3. cmb_t_prefix

Next Step

  2. Determine Combined Prefix
  3. cmb_n_prefix

Next Step

  2. Determine Combined Prefix
  3. cmb_m_prefix

Next Step

  2. Concatenate T
  3. Combined T

Next Step

  2. Concatenate N
  3. Combined N

Next Step

  2. Concatenate M
  3. Combined M

Next Step

  2. TNM 7 Path Stage Group
  3. Combined Stage Group

End

Outputs

Name Default Value Description NAACCR Item Metadata
Derived Version {{ctx_alg_version}} None None
Derived SEER Clin Stage Group 88 NAACCR #3610
derivedSeerClinStgGrp 		None
Derived SEER Path Stage Group 88 NAACCR #3605
derivedSeerPathStgGrp 		None
Derived SEER Combined Stage Group 88 NAACCR #3614
derivedSeerCmbStgGrp 		None
Derived SEER Combined T 88 NAACCR #3616
derivedSeerCombinedT 		None
Derived SEER Combined N 88 NAACCR #3618
derivedSeerCombinedN 		None
Derived SEER Combined M 88 NAACCR #3620
derivedSeerCombinedM 		None
Derived SEER Combined T Source <BLANK> NAACCR #3622
derivedSeerCmbTSrc 		None
Derived SEER Combined N Source <BLANK> NAACCR #3624
derivedSeerCmbNSrc 		None
Derived SEER Combined M Source <BLANK> NAACCR #3626
derivedSeerCmbMSrc 		None