Liver

Primary Site Histology Staging Type
C220 8000-8157, 8162-8169, 8190-9136, 9141-9582, 9700-9701 Summary Stage only
C220 8170-8175 TNM 7 and Summary Stage
C221 8170-8175 Summary Stage only

If you are working with a site/histology that only summary stages and you need to directly code it, please use the SEER Summary Stage 2000 manual

Notes

C220 Liver
C221 Intrahepatic bile duct

Note 1: This schema is based on the UICC chapter Liver-Hepatocellular Carcinoma pages 110-113.

  • Primary site C221 with histologies 8170-8175 is not listed in this chapter of the UICC manual; however, it is included in this schema, but is not TNM staged

Note 2: For primary site C220 and cholangiocarcinoma histologies (M-8160, 8161, and 8180), see the Bile DuctsIntraHepat schema.

Note 3: Although the presence of cirrhosis is an important prognostic factor, it does not affect the TNM classification, being an independent prognostic variable.

Note 4: In addition to directly assigning TNM, Summary Stage 2000 (SS2000) must be captured. If directly assigning SS2000, use the Liver and Intrahepatic Bile Ducts chapter on page 108 of the SS2000 on-line manual.

Main Data Items

Name Default Value Used for Staging NAACCR Item Required By Metadata
Clinical T <BLANK> Yes NAACCR #940
tnmClinT
None
Clinical N <BLANK> Yes NAACCR #950
tnmClinN
None
Clinical M <BLANK> Yes NAACCR #960
tnmClinM
None
TNM Clin Stage Group 99 Yes NAACCR #970
tnmClinStageGroup
None
Pathologic T <BLANK> Yes NAACCR #880
tnmPathT
None
Pathologic N <BLANK> Yes NAACCR #890
tnmPathN
None
Pathologic M <BLANK> Yes NAACCR #900
tnmPathM
None
TNM Path Stage Group 99 Yes NAACCR #910
tnmPathStageGroup
None
SSF1: Alpha Fetoprotein (AFP) Interpretation 999 No NAACCR #2880
csSiteSpecificFactor1
CCCR/Canada
COC
SEER
None
SSF2: Fibrosis Score 988 No NAACCR #2890
csSiteSpecificFactor2
CCCR/Canada
COC
None
SSF3: Alpha Fetoprotein (AFP) Lab Value 988 No NAACCR #2900
csSiteSpecificFactor3
CCCR/Canada
COC
None
SSF4: Creatinine Value 988 No NAACCR #2910
csSiteSpecificFactor4
CCCR/Canada
COC
None
SSF5: Creatinine Unit of Measure 988 No NAACCR #2920
csSiteSpecificFactor5
CCCR/Canada
COC
None
SSF6: Total Bilirubin Value 988 No NAACCR #2930
csSiteSpecificFactor6
CCCR/Canada
COC
None
SSF7: Total Bilirubin Unit of Measure 988 No NAACCR #2861
csSiteSpecificFactor7
CCCR/Canada
COC
None
SSF8: International Normalized Ratio for Prothrombin Time (INR) 988 No NAACCR #2862
csSiteSpecificFactor8
CCCR/Canada
COC
None

Additional Data Items

Name Default Value Used for Staging NAACCR Item Required By Metadata
Year of Diagnosis <BLANK> No NAACCR #390
dateOfDiagnosis
None
Primary Site <BLANK> Yes NAACCR #400
primarySite
None
Histology <BLANK> Yes NAACCR #522
histologicTypeIcdO3
None
RX Summ Systemic/Surgery Sequence <BLANK> Yes NAACCR #1639
rxSummSystemicSurSeq
None
RX Summ Surgery/Radiation Sequence <BLANK> Yes NAACCR #1380
rxSummSurgRadSeq
None
Regional Nodes Positive <BLANK> Yes NAACCR #820
regionalNodesPositive
None