Breast

Primary Site Histology Staging Type
C500-C506, C508-C509 8000-8576, 8940-8950, 8980-8981, 9020 TNM 7 and Summary Stage
C500-C506, C508-C509 8577-8939, 8951-8979, 8982-9019, 9021-9136, 9141-9582, 9700-9701 Summary Stage only

If you are working with a site/histology that only summary stages and you need to directly code it, please use the SEER Summary Stage 2000 manual

Notes

C500 Nipple C501 Central portion of breast C502 Upper-inner quadrant of breast C503 Lower-inner quadrant of breast C504 Upper-outer quadrant of breast C505 Lower-outer quadrant of breast C506 Axillary Tail of breast C508 Overlapping lesion of breast C509 Breast, NOS **Note 1:** This schema is based on the UICC chapter *Breast Tumours,* pages 181-193. * Primary sites C508 and C509 are listed in the chapter heading but are not specified in the anatomic subsites in this chapter of the UICC manual; however, they are included in this schema and TNM staged if appropriate histology criteria are met **Note 2:** Laterality must be coded for this site. **Note 3:** In addition to directly assigning TNM, Summary Stage 2000 (SS2000) must be captured. If directly assigning SS2000, use the *Breast* chapter on page 192 of the [SS2000 on-line manual](http://seer.cancer.gov/tools/ssm/SSSM2000-122012.pdf#page=192).

Main Data Items

Name Default Value Used for Staging NAACCR Item Required By Metadata
Clinical T <BLANK> Yes NAACCR #940 None
Clinical N <BLANK> Yes NAACCR #950 None
Clinical M <BLANK> Yes NAACCR #960 None
TNM Clin Stage Group 99 Yes NAACCR #970 None
Pathologic T <BLANK> Yes NAACCR #880 None
Pathologic N <BLANK> Yes NAACCR #890 None
Pathologic M <BLANK> Yes NAACCR #900 None
TNM Path Stage Group 99 Yes NAACCR #910 None
SSF1: Estrogen Receptor (ER) Assay 999 No NAACCR #2880 CCCR/Canada
COC
NPCR
SEER		 None
SSF2: Progesterone Receptor (PR) Assay 999 No NAACCR #2890 CCCR/Canada
COC
NPCR
SEER		 None
SSF3: Number of Positive Ipsilateral Level I-II Axillary Lymph Nodes 099 No NAACCR #2900 CCCR/Canada
SEER		 None
SSF4: Immunohistochemistry (IHC) of Regional Lymph Nodes 987 No NAACCR #2910 CCCR/Canada
SEER		 None
SSF5: Molecular (MOL) Studies of Regional Lymph Nodes 987 No NAACCR #2920 CCCR/Canada
SEER		 None
SSF6: Size of Tumor-Invasive Component 987 No NAACCR #2930 CCCR/Canada
COC
SEER		 None
SSF7: Nottingham or Bloom-Richardson (BR) Score/Grade 999 No NAACCR #2861 CCCR/Canada
COC
SEER		 None
SSF8: HER2: Immunohistochemistry (IHC) Lab Value 999 No NAACCR #2862 CCCR/Canada
COC
NPCR
SEER		 None
SSF9: HER2: Immunohistochemistry (IHC) Test Interpretation 999 No NAACCR #2863 CCCR/Canada
COC
NPCR
SEER		 None
SSF10: HER2: Fluorescence In Situ Hybridization (FISH) Lab Value 988 No NAACCR #2864 CCCR/Canada
COC		 None
SSF11: HER2: Fluorescence In Situ Hybridization (FISH) Test Interpretation 999 No NAACCR #2865 CCCR/Canada
COC
NPCR
SEER		 None
SSF12: HER2: Chromogenic In Situ Hybridization (CISH) Lab Value 988 No NAACCR #2866 CCCR/Canada
COC		 None
SSF13: HER2: Chromogenic In Situ Hybridization (CISH) Test Interpretation 999 No NAACCR #2867 CCCR/Canada
COC
NPCR
SEER		 None
SSF14: HER2: Result of Other or Unknown Test 999 No NAACCR #2868 CCCR/Canada
COC
NPCR
SEER		 None
SSF15: HER2: Summary Result of Testing 999 No NAACCR #2869 CCCR/Canada
COC
NPCR
SEER		 None
SSF16: Combinations of ER, PR, and HER2 Results 988 No NAACCR #2870 CCCR/Canada
NPCR		 None
SSF17: Circulating Tumor Cells (CTC) and Method of Detection 988 No NAACCR #2871 None None
SSF18: Disseminated Tumor Cells (DTC) and Method of Detection 988 No NAACCR #2872 None None
SSF19: Assessment of Positive Ipsilateral Axillary Lymph Nodes 988 No NAACCR #2873 None None
SSF20: Assessment of Positive Distant Metastases 988 No NAACCR #2874 None None
SSF21: Response to Neoadjuvant Therapy 988 No NAACCR #2875 CCCR/Canada
COC		 None
SSF22: Multigene Signature Method 999 No NAACCR #2876 CCCR/Canada
COC
SEER		 None
SSF23: Multigene Signature Results 999 No NAACCR #2877 CCCR/Canada
COC
SEER		 None
SSF24: Paget Disease 988 No NAACCR #2878 None None

Additional Data Items

Name Default Value Used for Staging NAACCR Item Required By Metadata
Year of Diagnosis <BLANK> No NAACCR #390 None
Primary Site <BLANK> Yes NAACCR #400 None
Histology <BLANK> Yes NAACCR #522 None
Behavior <BLANK> No NAACCR #523 None
RX Summ Systemic/Surgery Sequence <BLANK> Yes NAACCR #1639 None
RX Summ Surgery/Radiation Sequence <BLANK> Yes NAACCR #1380 None
Regional Nodes Positive <BLANK> Yes NAACCR #820 None

Initial Context

Staging Methods

Expand All | Collapse All

TNM 7 Stage

Inclusion Table

Histology
8000-8576
8940-8950
8980-8981
9020

Start

Additional Context
Pathologic Stage Group = 90
Clinical Stage Group = 90

Next Step

  2. Parse T
  3. clin_t_prefix
    tmp_clin_t

Next Step

  2. Parse N
  3. clin_n_prefix
    tmp_clin_n

Next Step

  2. Parse M
  3. tmp_clin_m
    clin_m_prefix

Next Step

  2. Parse T
  3. tmp_path_t
    path_t_prefix

Next Step

  2. Parse N
  3. tmp_path_n
    path_n_prefix

Next Step

  2. Parse M
  3. tmp_path_m
    path_m_prefix

Next Step

  2. Determine Default T
  3. Source T
    tmp_path_t
    tmp_clin_t
    tmp_combined_t

Next Step

  2. Determine Default N
  3. tmp_combined_n
    tmp_clin_n
    tmp_path_n
    Source N

Next Step

  2. Determine Default M
  3. tmp_path_m
    tmp_combined_m
    tmp_clin_m
    Source M

Next Step

  2. TNM 7 Stage Group
  3. Clinical Stage Group

Next Step

  2. TNM 7 Path Stage Group
  3. Pathologic Stage Group

Next Step

  2. Adjustments for No Clin or No Path
  3. tmp_combined_n
    tmp_combined_m
    Source T
    Clinical Stage Group
    Pathologic Stage Group
    Source N
    tmp_combined_t
    Source M

End

Combined Stage

Inclusion Table

Histology
8000-8576
8940-8950
8980-8981
9020

Start

Additional Context
Combined Stage Group = 90
Combined N = 90
Combined M = 90
Combined T = 90

Next Step

  2. Stop if No Clin and No Path
  3. Combined M
    Combined N
    Source T
    tmp_continue
    Combined T
    Combined Stage Group
    Source N
    ss2017
    Source M

Next Step

  2. Combined T Breast
  3. Source T
    tmp_combined_t

Next Step

  2. Combined N
  3. tmp_combined_n
    Source N

Next Step

  2. Combined M
  3. tmp_combined_m
    tmp_source_m
    Source M

Next Step

  2. Determine Combined Prefix
  3. cmb_t_prefix

Next Step

  2. Determine Combined Prefix
  3. cmb_n_prefix

Next Step

  2. Determine Combined Prefix
  3. cmb_m_prefix

Next Step

  2. Concatenate T
  3. Combined T

Next Step

  2. Concatenate N
  3. Combined N

Next Step

  2. Concatenate M
  3. Combined M

Next Step

  2. TNM 7 Path Stage Group
  3. Combined Stage Group

End

Outputs

Name Default Value Description NAACCR Item Metadata
Derived Version 1.1 None None
Derived SEER Clin Stage Group 88 NAACCR #3610
None 		None
Derived SEER Path Stage Group 88 NAACCR #3605
None 		None
Derived SEER Combined Stage Group 88 NAACCR #3614
None 		None
Derived SEER Combined T 88 NAACCR #3616
None 		None
Derived SEER Combined N 88 NAACCR #3618
None 		None
Derived SEER Combined M 88 NAACCR #3620
None 		None
Derived SEER Combined T Source <BLANK> NAACCR #3622
None 		None
Derived SEER Combined N Source <BLANK> NAACCR #3624
None 		None
Derived SEER Combined M Source <BLANK> NAACCR #3626
None 		None