Clinical M

This input is used for staging

Notes

**Note 1:** Distant lymph node involvement is coded as N2 for TNM staging for retinoblastoma and is collected in M (distant metastasis). **Note 2:** Code single and multiple metastatic lesions in this field based on the presentation of metastases in all distant sites excluding distant lymph nodes. **Note 3:** Metastasis to bone marrow is a single site of involvement.

NAACCR Item

NAACCR #960
Clinical M Clinical M Display Description Registrar Notes
c0 cM0 No distant metastasis Unknown; distant metastasis not stated
Distant metastasis cannot be assessed
Not documented in patient record
c1 cM1 Distant metastasis CLINICAL assessment only:
Note: M1 has subcategories of M1a, M1b, M1c, M1d and M1e. Assign M1 only when there is no information available to assign one of the subcategories

Distant metastasis WITH or WITHOUT distant lymph nodes

Distant metastasis, NOS

Stated as M1[NOS]
c1A cM1a Not defined by UICC* CLINICAL assessment only:
Single metastasis to sites other than CNS

Stated as M1a
c1B cM1b Not defined by UICC* CLINICAL assessment only:
Multiple metastasis to sites other than CNS

Stated as M1b
c1C cM1c Not defined by UICC* CLINICAL assessment only:
CNS metastasis
CNS location not specified

Stated as M1c
c1D cM1d Not defined by UICC* CLINICAL assessment only:
Discrete mass(es) with leptomeningeal and/or CSF involvement
Postchiasmatic lesions

Stated as M1d
c1E cM1e Not defined by UICC* CLINICAL assessment only:
Leptomeningeal and/or Cerebral Spine Fluid (CSF) involvement

Stated as M1e
p1 pM1 Distant metastasis HISTOLOGICALLY confirmed:
Note: M1 has subcategories of M1a, M1b, M1c, M1d and M1e. Assign M1 only when there is no information available to assign one of the subcategories

Distant metastasis WITH or WITHOUT distant lymph nodes

Distant metastasis, NOS
p1A pM1a Single metastasis to sites other than CNS HISTOLOGICALLY confirmed
p1B pM1b Multiple metastasis to sites other than CNS HISTOLOGICALLY confirmed
p1C pM1c CNS metastasis HISTOLOGICALLY confirmed:
CNS location not specified
p1D pM1d Discrete mass(es) without leptomeningeal and/or CSF involvement HISTOLOGICALLY confirmed:
Postchiasmatic lesions
p1E pM1e Leptomeningeal and/or Cerebral Spine Fluid (CSF) involvement HISTOLOGICALLY confirmed
88 88 Not applicable Primary site/histology not TNM defined
Death certificate only (DCO) case
<BLANK> BLANK See Registrar Notes Clinical classification criteria not met
Clinical classification criteria met, evaluation done:
No information about diagnostic workup
Results not documented in patient record
Clinical evaluation of T and N not done, no evidence metastatic disease
Tumor first detected on surgical resection (no clinical workup)
Only Clinical Stage Group documented (no T, N, or M information available)
\* This subcategory of clinical M1 is not defined in UICC 7th edition. Approval has been provided by UICC to use the definition from the AJCC 7th edition, which is documented in the registrar notes.