Site-Specific Factor 14

PDGFRA Gene Mutation


**Note 1:** Some gastrointestinal stromal tumors (GIST) have oncogenic mutations of the platelet-derived growth factor receptor alpha (PDGFRA) gene, located on chromosome 4q. This test is a special molecular diagnostic test performed on tumor tissue to identify PDGFRA mutations. Some GISTs that are negative for KIT mutations are positive for PDGFRA mutation. **Note 2:** Code the result of the PDGFRA gene test. Another name for PDGFRA is CD140A. **Note 3:** See **Site-Specific Factor 12, KIT Gene Immunohistochemistry (IHC) and Site Specific Factor 13, KIT Gene Mutations** for coding information about KIT gene expression and mutations.




NAACCR #2868
Code Description
010 PDGFRA gene test positive for mutations
020 PDGFRA gene test negative for mutations; no mutations; normal or wild-type gene
988 Not applicable: Information not collected for this case
997 Test ordered, results not in chart; results pending
998 Test not done (test not ordered and not performed)
999 Unknown or no information
Not documented in patient record