Pathologic T

This input is used for staging


**Note 1:** Assign 88 for in situ cases (behavior code /2). TNM does not include an in situ category for mucosal melanoma tumors. **Note 2:** Mucosal melanomas are aggressive tumors, therefore, T1 and T2 are omitted, as are Stages I and II. **Note 3:** Assign T3 for localized tumor when no other information is available or for extension involving the mucosa only of adjacent sites. **Note 4:** Assign T4a or T4b for extension involving the deeper tissues of the primary or adjacent sites.


Pathologic T Pathologic T Display Description Registrar Notes
pX pTX Primary tumor cannot be assessed# Pathologic classification criteria met, evaluation done:
Physician unable to assess T
Surgical resection of primary tumor, extension not stated
Physician assigns pTX, no other information available to determine T
p0 pT0 No evidence of primary tumor#
p3 pT3 Tumor limited to the epithelium and/or submucosa (mucosal disease) Tumor confined to mucosa of supraglottis:
Supraglottis (one subsite):
Aryepiglottic fold
Arytenoid cartilage:
Corniculate cartilage
Cuneiform cartilage
Epilarynx, NOS
False cords:
Ventricular bands
Ventricular cavity
Ventricular fold
Infrahyoid epiglottis
Laryngeal cartilage, NOS
Laryngeal (posterior) surface of epiglottis
Suprahyoid epiglottis (including tip, lingual {anterior} and laryngeal surfaces)
WITH normal vocal cord mobility

Extension involving mucosa only of glottic larynx or subglottis WITHOUT impaired vocal cord mobility or fixation of larynx or NOS

Extension involving mucosa only of adjacent regions(s) outside supraglottis including:
Mucosa of base of tongue
Medial wall of pyriform sinus
WITHOUT impaired vocal cord mobility or fixation of larynx or NOS

Stated as T3
p4 pT4 Not defined by UICC*# Note: T4 has subcategories of T4a and T4b. Assign T4 only when there is no information available to assign one of the subcategories

Tumor invades bone, nerve or extrinsic deep muscles

Stated as T4[NOS]
p4A pT4a Tumor invades:
Deep soft tissue
Overlying skin
Involvement of deep tissues of any structure in T3
Involvement of any structures in T3 WITH impaired vocal cord mobility
Involvement of any structures in supraglottic larynx and subglottic larynx WITH vocal cord fixation

Paraglottic space WITHOUT vocal cord fixation
Minor thyroid cartilage erosion (inner cortex) WITHOUT vocal cord fixation

Tumor involves further regions outside the supraglottis including:
Deep tissues or musculature:
Base of tongue
Medial wall pyriform sinus
Hypopharynx, NOS
Pre-epiglottic tissues
Postcricoid area
Pyriform sinus, NOS
WITH or WITHOUT vocal cord fixation

Extension to/through:
Cricoid cartilage
Deep extrinsic muscles of tongue
Soft tissues of neck
Strap muscle(s):
Thyroid cartilage
Thyroid gland

Stated as T4a
p4B pT4b Tumor invades any of the following:
Skull base
Lower cranial nerves (IX, X, XI, XII)
Masticator space
Carotid artery
Prevertebral space
Mediastinal structures
Contiguous extension, including:
Carotid artery (encased)
Mediastinal structures

Stated as T4b
88 88 Not applicable In situ case but no pTis is defined by TNM
Death certificate only (DCO) case
<BLANK> BLANK See Registrar Notes Pathologic classification criteria not met
Pathologic classification criteria met, evaluation done:
Results not documented in patient record
No surgical resection of known primary tumor (not T0)
Resection insufficient for site-specific pathologic assessment
No surgical resection of primary tumor and there isn’t a positive biopsy of a structure in the highest T category and highest N category
Evidence of metastatic disease (pM1), no other workup
Only Pathologic Stage Group documented (no T, N, or M information available)
\* T4 [NOS] is not defined by UICC in the 7th edition. Approval has been provided by UICC to use "Tumor invades bone, nerve or extrinsic deep muscles" as T4 [NOS]. \# TX, T0 and T4 [NOS] are not defined in AJCC 7th edition.