Site-Specific Factor 4

Methylation of O6-Methylguanine-Methyltransferase (MGMT)

Notes

**Note 1:** O6-methylguanine-methyltransferase (MGMT) is an enzyme in cells that repairs DNA. DNA repair is undesirable in tumors, because they may be able to overcome the DNA damage done by chemotherapy. With methylation, less MGMT enzyme is produced, which may lead to prolonged survival compared to unmethylated MGMT. **Note 2:** Code the methylation status of the MGMT gene (also termed MGMT promoter) as stated in the medical record. A positive test result may be termed "methylated," "hypermethylated," or "high." A negative result may be termed "unmethylated" or "low." This molecular test is not part of a routine pathology report.

Default

988

NAACCR Item

NAACCR #2910

Metadata

None
Code Description
010 Gene status methylated
Hypermethylated
High levels of methylation
020 Gene status unmethylated
Low levels of methylation
988 Not applicable: Information not collected for this case
998 No histologic examination of primary site
Test not done (test not ordered and not performed)
999 Unknown or no information
Not documented in patient record