Clinical T

This input is used for staging


**Note:** Ignore extension from gallbladder to cystic duct. Ignore extension to extrahepatic bile ducts or ampulla of Vater (T3) when other structures in T4 are involved.


Clinical T Clinical T Display Description Registrar Notes
cX cTX Primary tumor cannot be assessed Clinical classification criteria met, evaluation done:
Physician unable to assess T
Extension cannot be determined
Physician assigns cTX, no other information available to determine T
c0 cT0 No evidence of primary tumor
pIS pTis Carcinoma in situ Intraepithelial, noninvasive

Stated as Tis
c1 cT1 Tumor invades lamina propria or muscular layer Note: T1 has subcategories of T1a and T1b. Assign T1 only when there is no information available to assign one of the subcategories

Confined to gallbladder, NOS
Localized, NOS

Stated as T1 [NOS]
c1A cT1a Tumor invades lamina propria Invasive tumor confined to:
Lamina propria
Mucosa, NOS
Submucosa (superficial invasion)

Stated as T1a
c1B cT1b Tumor invades muscular layer Muscularis propria

Stated as T1b
c2 cT2 Tumor invades perimuscular connective tissue; no extension beyond serosa or into liver Perimuscular connective tissue

Stated as T2
c3 cT3 Tumor perforates the serosa (visceral peritoneum) and/or directly invades the liver and/or one other adjacent organ or structure, such as:
Extrahepatic bile ducts
Invasion of/through serosa (visceral peritoneum)

Extension to:
Abdominal wall
Ampulla of Vater
Branch(es) of hepatic artery (right or left) but not into main portal vein or hepatic artery
Branch(es) of portal vein (right or left)
Cystic artery vein
Small intestine

Extension into:

Stated as T3
c4 cT4 Tumor invades main portal vein or hepatic artery or invades two or more extrahepatic organs or structures Extension to:
Common hepatic artery
Main portal vein
Hepatic artery, NOS
Portal vein, NOS

Further contiguous extension

Stated as T4
88 88 Not applicable Primary site/histology not TNM defined
Death certificate only (DCO) case
<BLANK> BLANK See Registrar Notes Clinical classification criteria not met
Clinical classification criteria met, evaluation done:
No information about diagnostic workup
Results not documented in record
Clinical evaluation of primary tumor not done or unknown if done
Tumor first detected on surgical resection (no clinical workup)
Evidence of metastatic disease [(cM1) or (pM1)], no other workup
Only Clinical Stage Group documented (no T, N, or M information available)