Site-Specific Factor 16

Combinations of ER, PR, and HER2 Results

Notes

**Note 1:** There is a clinical interest in triple negative breast cancer, or breast cancer that is negative for estrogen receptors (ER), progesterone receptors (PR), and Human Epidermal Growth Factor Receptor 2 (HER2) amplification or overexpression. **Note 2:** This field is based on **Site-Specific Factors 1, 2 and 15**. **Note 3:** ER results are coded in the first digit: 0 for negative and 1 for positive. **Note 4:** PR results are coded in the second digit: 0 for negative and 1 for positive. **Note 5:** HER2 results are coded in the third digit: 0 for negative and 1 for positive. **Note 6:** If information is unknown or not available for one or more of the three types of tests, or if one or more of the three types of tests was not performed, code 999.

Default

988

NAACCR Item

NAACCR #2870

Metadata

None
Code Description
000 ER Negative, PR Negative, HER2 Negative (Triple Negative)
001 ER Negative, PR Negative, HER2 Positive
010 ER Negative, PR Positive, HER2 Negative
011 ER Negative, PR Positive, HER2 Positive
100 ER Positive, PR Negative, HER2 Negative
101 ER Positive, PR Negative, HER2 Positive
110 ER Positive, PR Positive, HER2 Negative
111 ER Positive, PR Positive, HER2 Positive
988 Not applicable: Information not collected for this case
999 One or more tests not performed
One or more tests unknown if performed
One or more tests with unknown or borderline results
Unknown or no information
Not documented in patient record