Site-Specific Factor 4
Methylation of O6-Methylguanine-Methyltransferase (MGMT)
Notes
**Note 1:** O6-methylguanine-methyltransferase (MGMT) is an enzyme in cells that repairs DNA. DNA repair is undesirable in tumors, because they may be able to overcome the DNA damage done by chemotherapy. With methylation, less MGMT enzyme is produced, which may lead to prolonged survival compared to unmethylated MGMT. **Note 2:** Code the methylation status of the MGMT gene (also termed MGMT promoter) as stated in the medical record. A positive test result may be termed "methylated," "hypermethylated," or "high." A negative result may be termed "unmethylated" or "low." This molecular test is not part of a routine pathology report.Default
988NAACCR Item
NAACCR #2910Metadata
None| Code | Description |
|---|---|
| 010 | Gene status methylated Hypermethylated High levels of methylation |
| 020 | Gene status unmethylated Low levels of methylation |
| 988 | Not applicable: Information not collected for this case |
| 998 | No histologic examination of primary site Test not done (test not ordered and not performed) |
| 999 | Unknown or no information Not documented in patient record |