NAACCR Item #1182: Lymphovascular Invasion

Item # Length Source of Standard Year Implemented Version Implemented Year Retired Version Retired
1,182 1 AJCC 2010 12

NAACCR XML: Tumor.lymphVascularInvasion

Alternate Names
   Lymph-vascular Invasion

Lymphovascular invasion (LVI) indicates the presence or absence of tumor cells in lymphatic channels (not lymph nodes) or blood vessels within the primary tumor as noted microscopically by the pathologist. LVI includes lymphatic invasion, vascular invasion, and lymphovascular invasion.


Presence or absence of cancer cells in the lymphatic ducts or blood vessels is useful for prognosis. CAP Protocols for some disease sites will be expanded to distinguish between lymphatic and small vessel invasion only, venous (large vessel) invasion only, and BOTH lymphatic and small vessel AND venous (large vessel) invasion.


0Lymphovascular Invasion stated as Not Present
1Lymphovascular Invasion Present/Identified (NOT used for thyroid and adrenal)
2Lymphatic and small vessel invasion only (L) OR Lymphatic invasion only (thyroid and adrenal only)
3Venous (large vessel) invasion only (V) OR Angioinvasion (thyroid and adrenal gland only)
4BOTH lymphatic and small vessel AND venous (large vessel) invasion OR BOTH lymphatic AND angioinvasion (thyroid and adrenal only)
8Not Applicable
9Unknown/Indeterminate/not mentioned in path report