NAACCR Item #3941: NRAS Mutational Analysis

Item # Length Source of Standard Year Implemented Version Implemented Year Retired Version Retired
3941 1 NAACCR 2021 21

NAACCR XML: Tumor.nrasMutationalAnalysis

Description
NRAS is a signaling intermediate in the growth receptor pathway. Certain NRAS mutations predict poor response to anti-EGFR therapy in patients with metastatic colorectal cancer.
Rationale
NRAS mutational analysis is recommended in clinical guidelines for patients with metastatic colon cancer who are being considered for anti-EGFR therapy. It is a new data item for cases diagnosed 01/01/2021+.
Codes
0 Normal
NRAS negative; NRAS wild type
Negative for (somatic) mutations, no alterations, no (somatic) mutations identified, not present, not detected
1 Abnormal (mutated)/detected in codon(s) 12, 13, and/or 61
2 Abnormal (mutated)/detected, codon(s) specified but not in codon(s) 12, 13, or 61
4 Abnormal (mutated), NOS, codon(s) not specified
7 Test ordered, results not in chart
8 Not applicable: Information not collected for this case
If this information is required by your standard setter, use of code 8 may result in an edit error.
9 Not documented in medical record
NRAS not assessed or unknown if assessed
Each Site-Specific Data Item (SSDI) applies only to selected primary sites, histologies, and years of diagnosis. Depending on applicability and standard-setter requirements, SSDIs may be left blank.