NAACCR Item #3940: BRAF Mutational Analysis

Item # Length Source of Standard Year Implemented Version Implemented Year Retired Version Retired
3940 1 NAACCR 2021 21

NAACCR XML: Tumor.brafMutationalAnalysis

Description
The BRAF oncoprotein is involved in transmitting cell growth and proliferation signals from KRAS and NRAS. The BRAF V600E mutation is associated with poorer prognosis and predicts lack of response to anti-EGFR therapies.
Rationale
BRAF mutational analysis is recommended in clinical guidelines for patients with advanced colorectal cancer as a prognostic marker and factor in determining appropriate therapy.  It is a new data item for cases diagnosed 1/1/2021+.
Codes
0 Normal
BRAF negative, BRAF wild type
Negative for (somatic) mutations, no alterations, no (somatic) mutations identified, not present, not detected
1 Abnormal (mutated)/detected: BRAF V600E (c.1799T>A) mutation
2 Abnormal (mutated)/detected, but not BRAF V600E (c.1799T>A) mutation
4 Abnormal (mutated), NOS
7 Test ordered, results not in chart
8 Not applicable: Information not collected for this case
If this information is required by your standard setter, use of code 8 may result in an edit error.)
9 Not documented in medical record
BRAF not assessed or unknown if assessed
Blank Diagnosis year is prior to 2021
Each Site-Specific Data Item (SSDI) applies only to selected primary sites, histologies, and years of diagnosis. Depending on applicability and standard-setter requirements, SSDIs may be left blank.