NAACCR Item #3894: Multigene Signature Method

Item # Length Source of Standard Year Implemented Version Implemented Year Retired Version Retired
3,894 1 NAACCR

NAACCR XML: Tumor.multigeneSignatureMethod


Multigene signatures or classifiers are assays of a panel of genes from a tumor specimen, intended to provide a quantitative assessment of the likelihood of response to chemotherapy and to evaluate prognosis or the likelihood of future metastasis. This data item identifies the multigene signature method used. Oncotype Dx is coded elsewhere.


Multigene Signature Method is a Registry Data Collection Variable in AJCC. It was previously collected as Breast, CS SSF #22. See also Multigene Signature Results.


2PAM50 (Prosigna)
3Breast Cancer Index
5Test performed, type of test unknown
6Multiple tests, any tests in codes 1-4
7Test ordered, results not in chart
8Not applicable: Information not collected for this case (If this item is required by your standard setter, use of code 8 will result in an edit error.)
9Not documented in medical record Multigene Signature Method not assessed or unknown if assessed

Each Site-Specific Data Item (SSDI) applies only to selected primary sites, histologies, and years of diagnosis. Depending on applicability and standard-setter requirements, SSDIs may be left blank.