EOD Data v2.1 NAACCR 2022

Multiple brain molecular markers have become standard pathology components necessary for diagnosis. This data item captures clinically important brain cancer subtypes identified by molecular markers that are not distinguishable by ICD-O-3 codes.

Collection of these clinically important brain cancer subtypes has been recommended by CBTRUS.

Definition

If a mutation or alteration is in the name of the histopathology, it is required for diagnosis as it helps distinguish among clinically important subtypes within ICD-O-3. 

• IDH mutation status distinguishes between clinically important subtypes within ICD-O-3 9400/3, Diffuse astrocytoma and 9401/3, Anaplastic astrocytoma.
• IDH mutant and 1p/19q co-deletion distinguishes between clinically important subtypes within ICD-O-3 code 9450/3, Oligodendroglioma and 9451/3, Anaplastic Oligodendroglioma.
• IDH-wildtype distinguishes clinically important subtypes within ICD-O-3 9400/3, Diffuse astrocytoma, 9401/3, Anaplastic astrocytoma and 9440/3, Glioblastoma, Epithelioid glioblastoma and Glioblastoma, NOS (note that the new ICD-O-3 code 9445/3 applies to Glioblastoma, IDH-mutant; information regarding this subtype is not collected using this data item).
• SHH-activation and TP53-wildtype distinguishes between clinically important subtypes within ICD-O-3 histology code 9471/3, Medulloblastoma.
• C19MC alteration status distinguishes a clinically important highly aggressive subtype within ICD-O-3 9478/3, Embryonal tumor with multilayered rosettes.
• Pediatric-type diffuse low-grade gliomas: 9385/3 Diffuse hemispheric glioma, H3-G34-mutant, Diffuse midline glioma, H3 K27-altered, Diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype, and Infant-type hemispheric glioma.
• Ependymal tumors are distinguished by mutations required for diagnosis among clinically important subtypes: 9396/3 Posterior fossa group A (PFA) ependymoma, Posterior fossa group B (PFB) ependymoma, Spinal ependymoma, _MYCN_-amplified, Supratentorial ependymoma, YAPI fusion-positive, and Supratentorial ependymoma, ZFTA fusion-positive.
• Pediatric-type diffuse low-grade gliomas are distinguished among subtypes by mutations required for diagnosis: 9421/1 Diffuse astrocytoma, _MYB_-or _MYBL1_-altered, Diffuse low-grade glioma, MAPK pathway-altered, and Pilocytic astrocytoma.
• Circumscribed astrocytic tumors are distinguished among subtypes by mutations required for diagnosis: 9430/3 Astroblastoma, MN1-altered and Astroblastoma.
• Other CNS embryonal tumors are distinguished among subtypes by mutations required for diagnosis: 9500/3 CNS neuroblastoma_, FOXR2_-activated, CNS tumor with BCOR internal tandem duplication, and Neuroblastoma, NOS.

Each Site-Specific Data Item (SSDI) applies only to selected primary sites, histologies, and years of diagnosis. Depending on applicability and standard-setter requirements, SSDIs may be left blank.