NAACCR Item #3931: Serum Beta-2 Microglobulin Pretreatment Level

Item # Length Source of Standard Year Implemented Version Implemented Year Retired Version Retired
3,931 1 NAACCR 2018 18

NAACCR XML: Tumor.serumBeta2MicroglobulinPretxLvl


Serum Beta-2 Microglobulin is a protein that is found on the surface of many cells and plentiful on the surface of white blood cells. Increased production or destruction of these cells causes Serum β2 (beta-2) Microglobulin level to increase. Elevated Serum β2 (beta-2) Microglobulin level is a prognostic factor for plasma cell myeloma.


Serum Beta-2 Microglobulin Pretreatment Level is a prognostic factor required in AJCC 8th edition, Chapter 82 Plasma Cell Myeloma and Plasma Cell Disorders, for staging of plasma cell myeloma.


0β2-microglobulin \<3.5 mg/L
1β2-microglobulin =3.5 mg/L \<5.5 mg/L
2β2-microglobulin =5.5 mg/L
5Schema Discriminator 1: Plasma Cell Myeloma Terminology coded to 1 or 9
7Test ordered, results not in chart
9Not documented in medical record Serum Beta-2 Microglobulin Pretreatment Level not assessed or unknown if assessed

Each Site-Specific Data Item (SSDI) applies only to selected primary sites, histologies, and years of diagnosis. Depending on applicability and standard-setter requirements, SSDIs may be left blank.