EOD Mets

Notes

**Note 1:** **Benign/borderline tumors** * Code 00 for benign (behavior /0) and borderline (behavior /1) tumors. **Note 2:** **Distant metastasis** * Use code 70 when the only information is “distant metastasis, NOS,” and there is no documentation regarding the specific metastases. * If there are specific metastasis documented that are not listed in codes 15, 25, or 35, or 45, assign code 45 for “other specified distant metastasis.” **Note 3:** **Types of extension coded in this data item** * The following adjacent structures/sites, by direct or contiguous extension, are coded to 35. * Adjacent connective/soft tissue * Adjacent muscle * Bone * Circulating cells in cerebral spinal fluid (CSF) * Major blood vessel(s) * Meninges (e.g.; dura) * Multiple/multifocal tumors * Nerves (cranial, NOS) * Ventricular system **Note 4:** **Leptomeningeal metastases** * Leptomeningeal metastases, also known as carcinomatous meningitis and meningeal carcinomatosis, refers to the spread of malignant cells through the CSF space. * These cells can originate from primary CNS tumors (e.g., in the form of drop metastases), as well as from distant tumors that have metastasized via hematogenous spread (code 35).
Code Description SS2018 M
00 No distant metastasis Unknown if distant metastasis NONE
15 Tumor cells in the CSF * Circulating cells in cerebral spinal fluid (CSF) D
25 Intracranial spread beyond a single lesion All sites - Bone (skull) (see code 45 for other bone involvement) - Major blood vessel(s) - Meninges (e.g., dura) - Multiple/multifocal tumors - Nerves (cranial, NOS) - Tumor invades or encroaches upon ventricular system Brain tumors (C700, C710-C719) - Anterior cranial fossa - Brain stem - Cerebellum - Cerebrum (cerebral hemisphere) - Contralateral hemisphere - Hypothalamus - Middle cranial fossa - Pallium - Posterior cranial fossa - Suprasellar brain - Tapetum - Thalamus CNS tumors (C701, C709, C720-C729) - Adjacent connective tissue - Adjacent muscle - Brain for cranial nerve tumor(s) - Sphenoid and frontal sinuses(skull) Pineal Gland (C753) - Adjacent connective/soft tissue - Cavernous sinus - Infratentorial and central brain D
35 Visible metastasis in spine OR Visible metastasis in cervicomedullary (junction) Metastasis within CNS and CSF pathways * Carcinomatous meningitis * Drop metastasis * Leptomeningeal metastases * Meningeal carcinomatosis D
45 Extra-neural metastasis All Sites - Blood - Bone (other than skull) (see code 25 for skull) - Bone marrow - Carcinomatosis - Distant lymph nodes, NOS - Further contiguous extension - Other specified metastasis Brain tumors (C700, C710-C719) - Nasal cavity - Nasopharynx - Other direct extension outside CNS - Posterior pharynx CNS tumors (C701, C709, C720-729) - Eye D
70 Distant metastasis, NOS D
99 Death Certificate Only U
(1) Fritz AG, Ries LAG (eds). **SEER Extent of Disease 1988: Codes and Coding Instructions (3rd Edition, 1998)**, National Cancer Institute, NIH Pub. No. 98-2313, Bethesda, MD, 1998 (2) Young JL Jr, Roffers SD, Ries LAG, Fritz AG, Hurlbut AA (eds.). **SEER Summary Staging Manual-2000: Codes and Coding Instructions**, National Cancer Institute, NIH Pub. No. 01-4969, Bethesda, MD, 2001. (3) Collaborative Stage Work Group of the American Joint Committee on Cancer. **Collaborative Stage Data Collection System User Documentation and Coding Instructions, version 02.05**. American Joint Committee on Cancer (Chicago, IL) (4) **Brain and Spinal Cord**, from the AJCC Cancer Staging System Version 9 (2022). Used with permission of the American College of Surgeons, Chicago, Illinois.