EOD Mets
Notes
**Note 1:** **Benign/borderline tumors**
* Code 00 for benign (behavior /0) and borderline (behavior /1) tumors.
**Note 2:** **Distant metastasis**
* Use code 70 when the only information is “distant metastasis, NOS,” and there is no documentation regarding the specific metastases.
* If there are specific metastasis documented that are not listed in codes 15, 25, or 35, or 45, assign code 45 for “other specified distant metastasis.”
**Note 3:** **Types of extension coded in this data item**
* The following adjacent structures/sites, by direct or contiguous extension, are coded to 35.
* Adjacent connective/soft tissue
* Adjacent muscle
* Bone
* Circulating cells in cerebral spinal fluid (CSF)
* Major blood vessel(s)
* Meninges (e.g.; dura)
* Multiple/multifocal tumors
* Nerves (cranial, NOS)
* Ventricular system
**Note 4:** **Leptomeningeal metastases**
* Leptomeningeal metastases, also known as carcinomatous meningitis and meningeal carcinomatosis, refers to the spread of malignant cells through the CSF space.
* These cells can originate from primary CNS tumors (e.g., in the form of drop metastases), as well as from distant tumors that have metastasized via hematogenous spread (code 35).
| Code |
Description |
SS2018 M |
| 00 |
No distant metastasis
Unknown if distant metastasis |
NONE |
| 15 |
Tumor cells in the CSF
* Circulating cells in cerebral spinal fluid (CSF) |
D |
| 25 |
Intracranial spread beyond a single lesion
All sites
- Bone (skull) (see code 45 for other bone involvement)
- Major blood vessel(s)
- Meninges (e.g., dura)
- Multiple/multifocal tumors
- Nerves (cranial, NOS)
- Tumor invades or encroaches upon ventricular system
Brain tumors (C700, C710-C719)
- Anterior cranial fossa
- Brain stem
- Cerebellum
- Cerebrum (cerebral hemisphere)
- Contralateral hemisphere
- Hypothalamus
- Middle cranial fossa
- Pallium
- Posterior cranial fossa
- Suprasellar brain
- Tapetum
- Thalamus
CNS tumors (C701, C709, C720-C729)
- Adjacent connective tissue
- Adjacent muscle
- Brain for cranial nerve tumor(s)
- Sphenoid and frontal sinuses(skull)
Pineal Gland (C753)
- Adjacent connective/soft tissue
- Cavernous sinus
- Infratentorial and central brain |
D |
| 35 |
Visible metastasis in spine OR
Visible metastasis in cervicomedullary (junction)
Metastasis within CNS and CSF pathways
* Carcinomatous meningitis
* Drop metastasis
* Leptomeningeal metastases
* Meningeal carcinomatosis |
D |
| 45 |
Extra-neural metastasis
All Sites
- Blood
- Bone (other than skull) (see code 25 for skull)
- Bone marrow
- Carcinomatosis
- Distant lymph nodes, NOS
- Further contiguous extension
- Other specified metastasis
Brain tumors (C700, C710-C719)
- Nasal cavity
- Nasopharynx
- Other direct extension outside CNS
- Posterior pharynx
CNS tumors (C701, C709, C720-729)
- Eye |
D |
| 70 |
Distant metastasis, NOS |
D |
| 99 |
Death Certificate Only |
U |
(1) Fritz AG, Ries LAG (eds). **SEER Extent of Disease 1988: Codes and Coding Instructions (3rd Edition, 1998)**, National Cancer Institute, NIH Pub. No. 98-2313, Bethesda, MD, 1998
(2) Young JL Jr, Roffers SD, Ries LAG, Fritz AG, Hurlbut AA (eds.). **SEER Summary Staging Manual-2000: Codes and Coding Instructions**, National Cancer Institute, NIH Pub. No. 01-4969, Bethesda, MD, 2001.
(3) Collaborative Stage Work Group of the American Joint Committee on Cancer. **Collaborative Stage Data Collection System User Documentation and Coding Instructions, version 02.05**. American Joint Committee on Cancer (Chicago, IL)
(4) **Brain and Spinal Cord**, from the AJCC Cancer Staging System Version 9 (2022). Used with permission of the American College of Surgeons, Chicago, Illinois.
