EOD Primary Tumor
**Note 1:** Periosteum is a fibrous membrane that wraps the outer surface of bones. Cortical bone is the dense compact outer layer of the bone. Trabecular, cancellous, or spongy bone (spongiosa) is a porous network of tissue filling the interior of bone, decreasing weight and allowing room for blood vessels and marrow.
**Note 2:** For codes 100-500, the derived EOD T is based on tumor size and depth of invasion. In addition, some of the anatomical structures listed are localized for Summary Stage 2018 while others are regional for Summary Stage 2018. The anatomical structures are divided into two groups: Group 1 is for localized tumors, while Group 2 is for regional tumor.
**Group 1 extension WITH any size tumor: Use the following for codes 100, 150, 200**
Invasive tumor confined to
Confined to buccal mucosa (inner cheek), NOS
**Group 2 extension WITH any size tumor: Use the following for codes 300, 400, 500**
Lateral pharyngeal wall
Lip(s) including commissure
Subcutaneous soft tissue of cheek
Tonsillar pillars and fossae
**Note 3:** Once the correct group is determined, the codes are then determined based on the depth of invasion.
* Depth of invasion less than or equal to 5 mm or UNKNOWN depth of invasion (codes 100, 300)
* Depth of invasion 5 mm to less than or equal to 10 mm (codes 150, 400)
* Depth of invasion greater than 10 mm (codes 200, 500)
**Note 4:** Involvement through cortical bone is required for assignment of code 600.
* Codes 300, 400, or 500 (depending on the depth of invasion) when the tumor is limited to the cortical bone/cortex of the mandible or maxilla. Invasion of the bone, NOS (mandible, NOS or maxilla, NOS) is **not** equivalent to invasion through the cortical bone (code 600).
(1) Fritz AG, Ries LAG (eds). **SEER Extent of Disease 1988: Codes and Coding Instructions (3rd Edition, 1998)**, National Cancer Institute, NIH Pub. No. 98-2313, Bethesda, MD, 1998
(2) Young JL Jr, Roffers SD, Ries LAG, Fritz AG, Hurlbut AA (eds.). **SEER Summary Staging Manual-2000: Codes and Coding Instructions**, National Cancer Institute, NIH Pub. No. 01-4969, Bethesda, MD, 2001.
(3) Collaborative Stage Work Group of the American Joint Committee on Cancer. **Collaborative Stage Data Collection System User Documentation and Coding Instructions, version 02.05**. American Joint Committee on Cancer (Chicago, IL)
(4) Gress, D.M., Edge, S.B., Gershenwald, J.E., et al. **Principles of Cancer Staging**. In: Amin, M.B., Edge, S.B., Greene, F.L., et al. (Eds.) AJCC Cancer Staging Manual. 8th Ed. New York: Springer; 2017: 3-30
(5) Lydiatt, W.M., Patel, S.G., Shah, J.P., et al. **Staging Head and Neck Cancers**. In: Amin, M.B., Edge, S.B., Greene, F.L., et al. (Eds.) AJCC Cancer Staging Manual. 8th Ed. New York: Springer; 2017: 55-65
(6) Ridge, J.A., Lydiatt, W.M., Shah, J.P., et al. **Lip and Oral Cavity**. In: Amin, M.B., Edge, S.B., Greene, F.L., et al. (Eds.) AJCC Cancer Staging Manual. 8th Ed. New York: Springer; 2017: 79-94