Oropharynx HPV-Mediated (p16+)

Primary Site Histology Schema Discriminator 1 Schema Discriminator 2
C019, C024, C051-C052, C090-C091, C098-C099, C100, C102-C104, C108-C109 8000-8700 <Any value> 2
C111 8000-8700 2 2

Notes

C019, C024, C051-C052, C090-C091, C098-C099, C100, C102-C104, C108-C109 and Schema Discriminator 2: Oropharyngeal p16: 2 (8000-8700) C111 and Schema Discriminator 1: Nasopharynx/PharyngealTonsil: 2 AND Schema Discriminator 2: Oropharyngeal p16: 2 (8000-8700) C019 Base of tongue, NOS C024 Lingual tonsil C051 Soft palate, NOS C052 Uvula C090 Tonsillar fossa C091 Tonsillar pillar C098 Overlapping lesion of tonsil C099 Tonsil, NOS C100 Vallecula C102 Lateral wall of oropharynx C103 Posterior wall of oropharynx C104 Branchial cleft (site of neoplasm) C108 Overlapping lesion of oropharynx C109 Oropharynx, NOS C111 Pharyngeal tonsil **Note 1:** The following sources were used in the development of this schema * SEER Extent of Disease 1988: Codes and Coding Instructions (3rd Edition, 1998) (https://seer.cancer.gov/archive/manuals/EOD10Dig.3rd.pdf) * SEER Summary Staging Manual-2000: Codes and Coding Instructions (https://seer.cancer.gov/tools/ssm/ssm2000/) * Collaborative Stage Data Collection System, version 02.05: https://cancerstaging.org/cstage/Pages/default.aspx * Chapter 10 *HPV-Mediated (p16+) Oropharyngeal Cancer*, in the AJCC Cancer Staging Manual, Eighth Edition (2017) published by Springer International Publishing. Used with permission of the American College of Surgeons, Chicago, Illinois. **Note 2:** See the following schemas for the listed histologies * C019, C024, C051-C052, C090-C091, C098-C099, C100, C102-C104, C108-C109 and Schema Discriminator 2: Oropharyngeal p16: 1, 9 (8000-8700): *Oropharynx (p16-)* * C111 and Schema Discriminator 1: Nasopharynx/PharyngealTonsil:1 (8000-8700): *Nasopharynx* * 8710-8714, 8800-8803, 8810-8905, 8912, 8921, 8932-8934, 8940-8990, 9000-9016, 9030-9043, 9045-9110, 9121-9138, 9141-9230, 9240-9580, 9582: *Soft Tissue Head and Neck* * 8720-8790: *Melanoma Head and Neck* * 8804-8806, 8910, 8920, 8930-8931, 8991, 9020, 9044, 9120, 9231, 9581: *Soft Tissue Rare* * 8935-8936: *GIST* * 8992: *Soft Tissue Other* * 9140: *Kaposi Sarcoma* * 9700-9701: *Mycosis Fungoides* **Note 3:** p16 immunotesting is mandatory to use this staging system for HPV-associated cancer. HPV by in situ hybridization (ISH) may be done as an alternative. If a case of oropharyngeal cancer has p16+, then this schema is used. If a case if p16- or does not have p16, then the Oropharynx (p16-) schema is used.

Data Items

Name Default Value Used for Staging NAACCR Item Required By Metadata
Year of Diagnosis <BLANK> No NAACCR #390
dateOfDiagnosis 		None
Primary Site <BLANK> Yes NAACCR #400
primarySite 		None
Histology <BLANK> Yes NAACCR #522
histologicTypeIcdO3 		None
Behavior <BLANK> Yes NAACCR #523
behaviorCodeIcdO3 		None
Schema Discriminator 1 <BLANK> Yes NAACCR #3926
schemaDiscriminator1 		All SSDI
Schema Discriminator 2 9 Yes NAACCR #3927
schemaDiscriminator2 		All SSDI
Tumor Size Clinical <BLANK> No NAACCR #752
tumorSizeClinical 		None
Tumor Size Pathological <BLANK> No NAACCR #754
tumorSizePathologic 		None
Tumor Size Summary 999 Yes NAACCR #756
tumorSizeSummary 		None
Regional Nodes Positive 99 Yes NAACCR #820
regionalNodesPositive 		None
Regional Nodes Examined 99 No NAACCR #830
regionalNodesExamined 		None
RX Summ Surgery/Radiation Sequence <BLANK> No NAACCR #1380
rxSummSurgRadSeq 		None
RX Summ Systemic/Surgery Sequence <BLANK> No NAACCR #1639
rxSummSystemicSurSeq 		None
EOD Primary Tumor 999 Yes NAACCR #772
eodPrimaryTumor 		None
EOD Regional Nodes 999 Yes NAACCR #774
eodRegionalNodes 		None
EOD Mets 00 Yes NAACCR #776
eodMets 		None
SS2018 <BLANK> No NAACCR #764
summaryStage2018 		None
Grade Clinical 9 Yes NAACCR #3843
gradeClinical 		All SSDI
Grade Pathological 9 Yes NAACCR #3844
gradePathological 		All SSDI
Grade Post Therapy Clin (yc) <BLANK> No NAACCR #1068
gradePostTherapyClin 		COC
NPCR
SEER		 SSDI
Grade Post Therapy Path (yp) <BLANK> No NAACCR #3845
gradePostTherapy 		CCCR/Canada
COC
NPCR
SEER		 SSDI
Extranodal Exten H&N Clin 8 No NAACCR #3831
extranodalExtensionHeadNeckClin 		COC
SEER (RC)		 SSDI
Extranodal Exten H&N Path X.8 No NAACCR #3832
extranodalExtensionHeadNeckPath 		CCCR/Canada
COC
SEER		 SSDI
Lymph Nodes Size XX.8 Yes NAACCR #3883
lnSize 		All SSDI
SEER_SSF1: SEER Site-Specific Fact 1 99 No NAACCR #3700
seerSiteSpecificFact1 		None

Initial Context

Staging Methods

Expand All | Collapse All

Summary Stage 2018

Start

Additional Context
eod_2018_t = 90
eod_2018_m = 90
eod_2018_n = 90

Next Step

  2. Derived Summary Grade
  3. derived_summary_grade

Next Step

  2. EOD Primary Tumor
  3. ss2018_t

Next Step

  2. EOD Regional Nodes
  3. ss2018_n

Next Step

  2. EOD Mets
  3. ss2018_m

Next Step

  2. Summary Stage
  3. ss2018_derived

End

Outputs

Name Default Value Description NAACCR Item Metadata
Schema ID 00100 NAACCR #3800
schemaId 		None
Derived Version {{ctx_alg_version}} None None
Derived Summary Stage 2018 9 NAACCR #762
derivedSummaryStage2018 		None
Derived Summary Grade 2018 <BLANK> NAACCR #1975
derivedSummaryGrade2018 		None