Human Papilloma Virus (HPV) Status
Description
***SEER Site-specific Factor 1***, effective 01/01/2018, is reserved for human papilloma virus (HPV) status. This data item applies to the following schemas.
* **00071: Lip**: C003-C005, C008, C009
* **00072: Tongue Anterior**: C020-C023, C028-C029
* **00073: Gum**: C030, C031, C039, C062
* **00074: Floor of Mouth**: C040-C041, C048-C049
* **00075: Palate Hard**: C050
* **00076: Buccal Mucosa**: C060, C061
* **00077: Mouth Other**: C058-C059, C068-C069
* **00100: Oropharynx HPV-Associated (2018-2025)** *(Oropharynx (p16-))*: C019, C024, C051-C052, C090-C091, C098-C099, C100, C102-C104, C108-C109, C111
* *Primary site C111 for 2018-2024 only*
* **09100: Oropharynx HPV-Associated (2026)** *(Oropharynx (p16-))*: C019, C024, C051-C052, C090-C091, C098-C099, C100, C102-C104, C108-C109
* **Oropharynx HPV-Independent** *(Oropharynx HPV-Mediated (p16+))*: C019, C024, C051-C052, C090-C091, C098-C099, C100, C102-C104, C108-C109, C111
* *Primary site C111 for 2018-2024 only*
* **00112: Hypopharynx**: C129, C130-C132, C138-C139
Rationale
There is evidence that human papilloma virus (HPV) plays a role in the pathogenesis of some cancers. HPV testing may be performed for prognostic purposes; testing may also be performed on metastatic sites to aid in determination of the primary site.
Notes
***Please send questions for this data item to Ask a SEER Registrar (https://seer.cancer.gov/registrars/contact.html)***
**Note 1:** **Record HPV results based on pathological specimens**
* Record the results of any HPV testing performed on pathological specimens including surgical and cytological (from cell blocks) tissue from the primary tumor or a metastatic site, including
lymph nodes.
* Do not record the results of blood tests or serology.
**Note 2:** **Methods of HPV determination**
* There are several methods for determination of HPV status.
* The most frequently used test is IHC for p16 expression which is a surrogate marker for HPV infection.
* Other tests (based on ISH, PCR, RT-PCR technologies) detect the viral DNA or RNA.
**Note 3:** **HPV-type 16**
* HPV-type 16 refers to virus type and is different from p16 overexpression (p16+)
**Note 4:** **Codes are hierarchical**
* Codes 10-51 are hierarchical; use the highest code that applies (10 is lowest, 51 is highest)
**Note 5:** **For cases in the Oropharynx HPV-Independent schema**
* If an additional HPV test is done in addition to p16, code those test results in this data item
* If no additional HPV test is done
* Code 10 in this data item (Schema Discriminator 2 coded to 2)
**Note 6:** **For cases in the Oropharynx HPV-Associated schema**
* If an additional HPV test is done in addition to p16, code those test results in this data item
* If no additional HPV test is done
* Code 11 in this data item if Schema Discriminator 2 is coded to 1
* Code 99 in this data item if Schema Discriminator 2 is coded to 9
Default
99
Metadata
None
| Code |
Description |
| 10 |
HPV negative by p16 test |
| 11 |
HPV positive by p16 test |
| 20 |
HPV negative for viral DNA by ISH test |
| 21 |
HPV positive for viral DNA by ISH test |
| 30 |
HPV negative for viral DNA by PCR test |
| 31 |
HPV positive for viral DNA by PCR test |
| 40 |
HPV negative by ISH E6/E7 RNA test |
| 41 |
HPV positive by ISH E6/E7 RNA test |
| 50 |
HPV negative by RT-PCR E6/E7 RNA test |
| 51 |
HPV positive by RT-PCR E6/E7 RNA test |
| 70 |
HPV status reported in medical records as negative, but test type is unknown |
| 71 |
HPV status reported in medical records as positive, but test type is unknown |
| 97 |
Test done, results not in chart |
| 99 |
Not documented in medical record
HPV test not done, not assessed, or unknown if assessed |
