Serum Albumin Pretreatment Level
Description
Albumin is the most abundant protein in human blood plasma. Serum albumin pretreatment level is a prognostic factor for plasma cell myeloma. The Revised International Staging System (RISS or R-ISS) is now used to stage plasma cell myeloma (9732/3), using several different criteria. The stages are based on the absence or presence of the following related criteria. * 3931: Serum Beta-2 Microglobulin Pretreatment Level * 3930: Serum Albumin Pretreatment Level * 3857: High Risk Cytogenetics * 3869: LDH Level Required for Staging: The AJCC Staging System Plasma Cell Myeloma and Plasma Cell Disorders (9732/3 only) and EOD. * Note: RISS stage is not applicable for the descriptions of plasma multiple myeloma that are listed in the codes 1 and 9 in the SSDI Schema Discriminator 1: Plasma Cell Myeloma Terminology. If you have coded 1 or 9 for this Schema Discriminator, the four data items listed above are BLANK. The RISS stages are * Stage I: Serum Beta-2-microglobulin <3.5 mg/L and serum albumin > 3.5 g/dL and no high-risk cytogenetics and Normal LDH * Stage II: Not R-ISS I or III * Stage III: Serum Beta-2-microglobulin > 5.5 mg/L and high-risk cytogenetics and/or high LDHRationale
Serum albumin pretreatment level is a prognostic factor required in AJCC 8th edition, Chapter 82 Plasma Cell Myeloma and Plasma Cell Disorders, for the Revised International Staging System (RISS). It is a new data item for cases diagnosed 1/1/2018+.Additional Info
**Source documents:** laboratory tests (blood only)Notes
**Note 1:** **Physician statement** * Physician statement of Serum Albumin Pretreatment Level can be used to code this data item when no other information is available **Note 2:** **Pretreatment results only** * Record this data item based on a **blood test** performed at diagnosis (pre-treatment). Use the highest value available. * Do not use results from a urine test **Note 3:** **Component of RISS Stage** * Serum albumin is part of the Revised International Staging (RISS). * Elevated serum albumin is defined by ≥3.5 g/dL * Use the cut points listed in the table below regardless of the lab’s reference range * A lab value expressed in grams per liter (g/L) is 10 times the same value expressed in g/dL; therefore, the cut point of 3.5 g/dL is equivalent to 35 g/LCoding Guidelines
**1) Code 5** if Schema Discriminator 1: Plasma Cell Myeloma Terminology is coded to 1 or 9 **2) Code 9** when there is no mention of the serum albuminDefault
9NAACCR Item
NAACCR #3930Metadata
SSDI| Code | Description |
|---|---|
| 0 | Serum albumin <3.5 g/dL |
| 1 | Serum albumin ≥3.5 g/dL |
| 5 | Schema Discriminator 1: Plasma Cell Myeloma Terminology coded to 1 or 9 |
| 7 | Test ordered, results not in chart |
| 9 | Not documented in medical record Serum Albumin not assessed or unknown if assessed |