Neoadjuvant Therapy-Treatment Effect
Description
This data item records the pathologist’s statement of neoadjuvant treatment effect on the primary tumor from the surgical pathology report. Whenever treatment effect definitions are recommended by or available in CAP Cancer Protocols, this data item follows the CAP definitions indicating absent or present effect. When specific CAP definitions are not available, registrars should use treatment effect general use categories.
Notes
This data item provides information related to the quality of care and describes the pathological outcomes after neoadjuvant therapy. This data item provides prognostically relevant information by quantifying the extent of therapy-induced tumor regression. Therefore, this item can provide a better risk stratification for patients who received neoadjuvant therapy. In addition, this data item can contribute to assessments of cancer care quality.
See the [SEER Coding Manual](https://seer.cancer.gov/manuals/2023/SPCSM_2023_MainDoc.pdf) for additional information.
Default
9
Metadata
None
| Code |
Description |
| 0 |
Neoadjuvant therapy not given/no known presurgical therapy |
| 1 |
No definite or minimal response identified
Stated as Chemotherapy response score 1 [CRS1] |
| 2 |
Moderate response identified
Stated as Chemotherapy response score 2 [CRS2] |
| 3 |
Marked response with no or minimal residual cancer
Stated as Chemotherapy response score 3 [CRS3] |
| 4 |
Residual tumor, not specified as minimal, moderate or marked
Not documented as CRS1, CRS2 or CRS3
Response, NOS |
| 6 |
Neoadjuvant therapy completed and surgical resection performed, response not documented or unknown;
Cannot be determined |
| 7 |
Neoadjuvant therapy completed and planned surgical resection not performed |
| 9 |
Unknown if neoadjuvant therapy performed;
Unknown if planned surgical procedure performed after completion of neoadjuvant therapy;
Death certificate only (DCO) |
