Extravascular Matrix Patterns
Description
Extravascular Matrix Patterns, the presence of loops and networks in extracellular matrix patterns, is a prognostic factor for uveal melanoma.
The presence of extravascular matrix patterns is an indicator for shorter survival. There are two different types of patterns: loops only, or loops forming networks. The identification of the complex monocirculatory patterns (i.e., loops, networks, arcs with branching, parallel with cross-linking or a combination of these patterns) are done using confocal indocyanine green angiography. The patterns are assessed with light microscopy under a dark green filter after staining with periodic-acid Schiff without counterstain. This determines the presence or absence of each matrix pattern, which appear deep purple against a pink background.
Rationale
Extravascular Matrix Patterns is a Registry Data Collection Variable in AJCC 8. This data item was previously collected as Uveal Melanoma, CS SSF #11, and CS SSF #12. These two data items were combined into one data for cases diagnosed 1/1/2018+.
Additional Info
**Source documents:** pathology report, confocal indocyanine green angiography report, clinician comment.
For further information, refer to the **Uveal Melanoma** cancer protocol published by the College of American Pathologists for the AJCC Staging System *Uveal Melanoma*
Notes
**Note:** **Physician Statement**
* Physician statement of extravascular matrix patterns can be used to code this data item when no other information is available.
Coding Guidelines
**1)** **Code 0** when pathology report states that loops and networks are not found
**2)** **Code 1** when pathology reports states networks and/or loops present
**3)** **Code 9** when
* **a.** Pathology report available and there is no mention of extravascular matrix patterns (loops or networks)
* **b.** Extravascular matrix patterns not assessed or unknown if assessed
Default
8
Metadata
SSDI
| Code |
Description |
| 0 |
Extravascular matrix patterns not present/not identified |
| 1 |
Extravascular matrix patterns present/identified |
| 8 |
Not applicable: Information not collected for this case
(If this information is required by your standard setter, use of code 8 may result in an edit error.) |
| 9 |
Not documented in medical record
Extravascular Matrix Patterns not assessed or unknown if assessed |
