PR (Progesterone Receptor) Total Allred Score
Description
Progesterone Receptor, Total Allred Score is based on the percentage of cells that stain by IHC for progesterone receptor (PR) and the intensity of that staining.
The Allred Score is a method of quantifying ER and PR using both intensity and percentage of positive cells. The Allred Score is calculated by adding the Proportion Score and the Intensity Score, as defined in the tables below.
The Allred score combines the percentage of positive cells (proportion score) and the intensity score of the reaction product in most of the carcinoma. The 2 scores are added together for a final score with 8 possible values (00-08).
Positive cells = 0; Proportion score = 0
Positive cells = <1; Proportion score = 1
Positive cells = 1 to 10; Proportion score = 2
Positive cells = 11 to 33; Proportion score = 3
Positive cells = 34 to 66; Proportion score = 4
Positive cells = 67 or greater; Proportion score = 5
Intensity = None; Intensity Score = 0
Intensity = Weak; Intensity Score = 1
Intensity = Intermediate/Moderate; Intensity Score = 2
Intensity = Strong; Intensity Score = 3
Rationale
Progesterone Receptor, Total Allred Score is a Registry Data Collection Variable in AJCC. It is a new data item for cases diagnosed 1/1/2018+.
Additional Info
**Source documents:** pathology report
For further information, refer to the **Breast Biomarker Reporting** cancer protocols published by the College of American Pathologists for the AJCC Staging System *Breast*
Notes
**Note 1:** **No longer required by any standard setter**
* This SSDI is no longer required by any of the standard setters starting with 2023 diagnoses
* For cases diagnosed 2023+, this SSDI may be left blank
**Note 2:** **Physician Statement**
* Physician statement of PR (Progesterone Receptor) Total Allred Score can be used to code this data item when no other information is available.
**Note 3:** **Related data item**
* Code this data item using the same report used to record the related data item 3915: Progesterone Receptor Summary.
Coding Guidelines
**1)** Registrar should not calculate the Allred Score unless both components are available (proportion score and intensity)
**2)** **Code X9** if PR test is performed, but Allred score is not documented, or cannot be calculated
Default
X8
Metadata
SSDI 2018–2022
| Code |
Description |
| 00 |
Total PR Allred score of 0 |
| 01 |
Total PR Allred score of 1 |
| 02 |
Total PR Allred score of 2 |
| 03 |
Total PR Allred score of 3 |
| 04 |
Total PR Allred score of 4 |
| 05 |
Total PR Allred score of 5 |
| 06 |
Total PR Allred score of 6 |
| 07 |
Total PR Allred score of 7 |
| 08 |
Total PR Allred score of 8 |
| X8 |
Not applicable: Information not collected for this case
(If this item is required by your standard setter, use of code X8 will result in an edit error.) |
| X9 |
Not documented in medical record
PR (Progesterone Receptor) Total Allred Score not assessed, or unknown if assessed |
| <BLANK> |
May be blank if diagnosis year is after 2022 |
