PR (Progesterone Receptor) Summary

This input is used for staging

Description

Progesterone Receptor Summary is a summary of results from the progesterone receptor (PR) assay. Estrogen receptor (ER) positivity and progesterone receptor (PR) positivity are favorable prognostic factors in breast cancer, as well as endometrial carcinoma and meningioma. Positive results predict a favorable response to endocrine (hormonal) therapy. Combined ER and PR positivity is associated with increased response to antiestrogen therapies. There are a variety of ways to report information on ER and PR results, but there is almost always a summary statement that the result is positive or negative.

Rationale

This data item is required for prognostic stage grouping in AJCC 8th edition, Chapter 48 Breast. It was previously collected as Breast CS SSF # 2.

Additional Info

**Source documents:** pathology report **For further information**, refer to the **Breast Biomarker Reporting** cancer protocols published by the College of American Pathologists for the AJCC Staging System Breast

Notes

**Note 1:** **Physician Statement** * Physician statement of PR (Progesterone Receptor) Summary status can be used to code this data item when no other information is available. **Note 2:** **In-situ and Invasive components present** * If PR is positive on an in-situ component and PR is negative on all tested invasive components in the primary tumor, code PR as negative (code 0) * If in situ and invasive components present and PR only done on the in-situ component in the primary tumor, code unknown (code 9) **Note 3:** **Single tumor, multiple biopsies or surgical resection, different results** * Use the highest (positive versus negative) **Note 4:** **Multiple tumors, different results** * Code the results from the largest tumor size (determined either clinically or pathologically) when multiple tumors are present. * Do not use specimen size to determine the largest tumor size **Note 5:** **Results from nodal or metastatic tissue** * May be used ONLY when there is no evidence of primary tumor * **Note:** In-situ is evidence of primary tumor **Note 6:** **Neoadjuvant Therapy** * Record the assay from tumor specimens prior to neoadjuvant therapy. * If neoadjuvant therapy is given and there are no ER results from pre-treatment specimens, report the findings from post-treatment specimens **Note 7:** **Others tests for PR** * Do not use results from the following tests to record PR results * MammaPrint * EndoPredict * PAM 50 (Prosigna) * Any other test that records PR

Coding Guidelines

**1)** **Code 0** when the PR is reported as negative or normal **2)** **Code 1** when the PR is reported as positive or elevated **3)** **Code 7** when the PR test was ordered but the results are not available **4)** **Code 9** when the PR is * **a.** Reported as borderline; undetermined whether positive or negative * **b.** Cannot be determined by the pathologist (e.g., inadequate specimen) * **c.** It is unknown whether the PR test was performed * **d.** The patient has only a clinical diagnosis of breast cancer (no tissue diagnosis)

Default

NAACCR Item

NAACCR #3915

Metadata

SSDI

Code	Description
0	PR negative (0.0% or less than 1%)
1	PR positive
7	Test ordered, results not in chart
9	Not documented in medical record Cannot be determined (indeterminate) PR (Progesterone Receptor) Summary status not assessed or unknown if assessed