EGFR Mutational Analysis

Notes

**Note 1:** This SSDI is effective for diagnosis years 2021+ * For cases diagnosed 2018-2020, leave this SSDI blank **Note 2:** Physician statement of EGFR can be used to code this data item when no other information is available. **Note 3:** EGFR may be recorded for all histologies and stages; however, it is primarily performed for advanced non-small cell carcinomas. If information is not available, code 9. **Note 4:** The most common EGFR mutations are * Exon 18 Gly719 * Exon 19 deletion * Exon 20 insertion * Exon 20 Thr790Met * Exon 21 Leu858Arg **Note 5:** If EGFR is positive and there is no mention of the mutated codon, or the mutated codon is not specified, code 4. **Note 6:** If neoadjuvant therapy is given, record the assay from tumor specimens prior to neoadjuvant therapy. * If neoadjuvant therapy is given and there are no EGFR results from pre-treatment specimens, report the findings from post-treatment specimens **Note 7:** Code 9 when * Insufficient amount of tissue available to perform test * No microscopic confirmation of tumor * EGFR not ordered or not done, or unknown if ordered or done

Default

8

NAACCR Item

NAACCR #3939

Metadata

SSDI 2021–
Code Description
0 Normal EGFR negative, EGFR wild type Negative for mutations, no alterations, no mutations (somatic) identified, not present, not detected
1 Abnormal (mutated)/detected in exon(s) 18, 19, 20, and/or 21
2 Abnormal (mutated)/detected but not in exon(s) 18, 19, 20, and/or 21
4 Abnormal (mutated)/detected, NOS, exon(s) not specified
7 Test ordered, results not in chart
8 Not applicable: Information not collected for this case (If this information is required by your standard setter, use of code 8 may result in an edit error.)
9 Not documented in medical record EGFR not assessed or unknown if assessed
<BLANK> N/A - Diagnosis year is prior to 2021