**Note 1:** This SSDI is effective for diagnosis years 2021+
* For cases diagnosed 2018-2020, leave this SSDI blank
**Note 2:** Code 0 for p16 expression of weak intensity or limited distribution.
**Note 3:** This data item must be based on testing results for p16 overexpression.
* A statement of a patient being HPV positive or negative is not enough to code this data item
* Testing for HPV by DNA, mRNA, antibody, or other methods should not be coded in this data item
* Do not confuse p16 with HPV 16, which is a specific strain of virus