Multigene Signature Result


**Note 1:** Physician statement of the Multigene Signature Results can be used to code this data item. **Note 2:** Multigene signatures or classifiers are assays of a panel of genes from a tumor specimen, intended to provide a quantitative assessment of the likelihood of response to chemotherapy and to evaluate prognosis or the likelihood of future metastasis. * Only record tests done on tumor tissue that help determine if the cancer is likely to recur. Don’t include other tests, such as those that evaluate hereditary mutations that influence a patient’s risk of developing cancer (e.g. myRisk, BRCA) * Only record tests that are based on gene assays. Don’t include other tests which use a multivariate data model to eliminate the need for genetic assays **Note 3:** Code the score or risk for the test performed. The same test should be used to record information in 3894: Multigene Signature Method. **Note 4:** Oncotype Dx tests are not recorded in this data item. See the following data items for Oncotype Dx. * 3903: Oncotype Dx Recurrence Score-DCIS * 3904: Oncotype Dx Recurrence Score-Invasive * 3905: Oncotype Dx Risk Level-DCIS * 3906: Oncotype Dx Risk Level-Invasive **Note 5:** PAM50 (Prosigna) is a single numeric score of 0-100. If the score is available, record the score. If only the risk level is available, record that. **Note 6:** For Mammaprint, EndoPredict, and Breast Cancer Index, only record the risk level.




NAACCR #3895


Code Description
00-99 Enter actual recurrence score Note: Depending on the test, the range of values may be different
X1 Score 100
X2 Low risk
X3 Moderate [intermediate] risk
X4 High risk
X7 Test done, results not in chart
X8 Not applicable: Information not collected for this case (If this item is required by your standard setter, use of code X8 will result in an edit error.)
X9 Not documented in medical record Multigene Signature Results not assessed or unknown if assessed