Testis Serum Markers (S) Clinical (pre orchiectomy)

This input is used for staging


S Category Clinical combines the results of pre-orchiectomy Alpha Fetoprotein (AFP), Human Chorionic Gonadotropin (hCG) and Lactate Dehydrogenase (LDH) into a summary S value.


**Note 1:** Code the S category as described by the physician. If the S category determined by available lab values or calculated by vendor software differs from the physician statement of the S category, the physician's statement takes precedence. **Note 2:** Code the pre-orchiectomy S category according to the table below. This table is also available in AJCC 8th edition, Chapter 59, Testis. * For AFP, a lab value expressed in micrograms per liter (ug/L) is equivalent to the same value expressed in nanograms per milliliter (ng/ml). **Note 3:** Clinical stage values are those based on physician statement or lab values at diagnosis, prior to orchiectomy, and prior to any systemic treatment. **Note 4:** All three lab values are needed for S0-S1. Only one elevated test is needed to assign S2-3. If any individual test is not available and none of the available tests results meets the S2-3 criterion for that test, assign code 9 (SX).




NAACCR #3923


Code Description
0 S0: Marker study levels within normal levels
1 S1: At least one of these values is elevated AND - LDH less than 1.5 x N* AND - hCG (mIU/L) less than 5,000 AND - AFP (ng/mL) less than 1,000
2 S2: - LDH 1.5 x N* to 10 x N* OR - hCG (mIU/L) 5,000 to 50,000 OR - AFP (ng/mL) 1,000 to 10,000
3 S3: Only one elevated test is needed - LDH greater than 10 x N* OR - hcG (mIU/mL) greater than 50,000 OR - AFP (ng/mL) greater than 10,000
9 SX: Not documented in medical record S Category Clinical not assessed or unknown if assessed