Grade Post Therapy Clin (yc)


**Note 1:** Leave Grade Post Therapy Clin (yc) blank when * No neoadjuvant therapy * Clinical or pathological case only * Neoadjuvant therapy completed, no microscopic exam is done prior to surgery/resection of primary tumor * There is only one grade available and it cannot be determined if it is clinical, pathological, post therapy clinical or post therapy pathological **Note 2:** Assign the highest grade from the microscopically sampled specimen of the primary site following neoadjuvant therapy or primary systemic/radiation therapy. **Note 3:** If there are multiple tumors with different grades abstracted as one primary, code the highest grade. **Note 4:** Codes 1-3 take priority over codes A-D. **Note 5:** Code 9 (unknown) when * Microscopic exam is done after neoadjuvant therapy and grade from the primary site is not documented * Microscopic exam is done after neoadjuvant therapy and there is no residual cancer * Grade checked “not applicable” on CAP Protocol (if available) and no other grade information is available


NAACCR #1068


Code Description
1 G1: Mitotic count (per 10 HPF or 2mm2) less than 2 AND Ki-67 index (%) less than 3 Stated as WHO Grade 1
2 G2: Mitotic count (per 10 HPF or 2mm2) equal 2-20 OR Ki-67 index (%) equal 3-20 Stated as WHO Grade 2
3 G3: Mitotic count (per 10 HPF or 2mm2) greater than 20 OR Ki-67 index (%) greater than 20 Stated as WHO Grade 3
A Well differentiated
B Moderately differentiated
C Poorly differentiated
D Undifferentiated, anaplastic
9 Grade cannot be assessed (GX); Unknown
<BLANK> See Note 1