Multigene Signature Method


**Note 1:** Physician statement of the Multigene Signature Method can be used to code this data item. **Note 2:** Multigene signatures or classifiers are assays of a panel of genes from a tumor specimen, intended to provide a quantitative assessment of the likelihood of response to chemotherapy and to evaluate prognosis or the likelihood of future metastasis. * Only record tests done on tumor tissue that help determine if the cancer is likely to recur. Don’t include other tests, such as those that evaluate hereditary mutations that influence a patient’s risk of developing cancer (e.g. myRisk, BRCA) **Note 3:** Code the type of test performed. The same test should be used to record information in Multigene Signature Results [NAACCR Data Item #3895]. **Note 4:** Oncotype Dx tests are not recorded in this data item. See the following data items for Oncotype Dx. * Oncotype Dx Recurrence Score-DCIS [NAACCR Data Item #3903] * Oncotype Dx Recurrence Score-Invasive [NAACCR Data Item #3904] * Oncotype Dx Risk Level-DCIS [NAACCR Data Item #3905] * Oncotype Dx Risk Level-Invasive [NAACCR Data Item #3906]




NAACCR #3894


Code Description
1 Mammaprint
2 PAM50 (Prosigna)
3 Breast Cancer Index
4 EndoPredict
5 Test performed, type of test unknown
6 Multiple tests, any tests in codes 1-4
7 Test ordered, results not in chart
8 Not applicable: Information not collected for this case (If this item is required by your standard setter, use of code 8 will result in an edit error.)
9 Not documented in medical record Multigene Signature Method not assessed or unknown if assessed