Chromosome 3 Status
**Note 1:** Physician statement of chromosome 3 status can be used to code this data item when no other information is available.
**Note 2:** Monosomy 3, especially if combined with a frequently coexisting gain in chromosome 8q, is independently associated with metastatic risk. Chromosome 3 and 8 statuses may be determined with karyotyping or fluorescent in situ hybridization (FISH).
**Note 3:** See also Chromosome 8q Status (NAACCR Data Item #3822)