Microvascular Density (MVD)
**Note 1:** Physician statement of microvascular density (MVD) can be used to code this data item when no other information is available.
**Note 2:** MVD is independently associated with metastatic risk. The number of immunopositive elements is labeled with a marker for vascular endothelial cells (e.g., CD34 epitope, CD31 epitope, factor VIII-related antigen) and counted from area of densest vascularization (typical field area, 0.3 mm2 squared). Higher counts are associated with shorter survival.
**Note 3:** Record the results as expressed on the laboratory test. Record the information based on quartiles for laboratory standards if this is the only expression of results.