Human Papilloma Virus (HPV) Status

Notes

**Note 1:** There is evidence that human papilloma virus (HPV) plays a role in the pathogenesis of some cancers. HPV testing may be performed for prognostic purposes; testing may also be performed on metastatic sites to aid in determination of the primary site. **Note 2:** Record the results of any HPV testing performed on pathological specimens including surgical and cytological (from cell blocks) tissue from the primary tumor or a metastatic site, including lymph nodes. Do not record the results of blood tests or serology. **Note 3:** There are several methods for determination of HPV status. The most frequently used test is IHC for p16 expression which is surrogate marker for HPV infection. **Do not record the results of IHC p16 expression in this field.** The rest of the tests (based on ISH, PCR, RT-PCR technologies) detect the viral DNA or RNA. **This data item is only for HPV status determined by tests designed to detect viral DNA or RNA.** **Note 4:** HPV-type 16 refers to virus type and is different from p16 overexpression (p16+). **Note 5:** Codes 0-7 are hierarchical; use the highest code that applies.

Default

9

NAACCR Item

NAACCR #3700

Metadata

SSDI
Code Description
0 HPV negative for viral DNA by ISH test
1 HPV positive for viral DNA by ISH test
2 HPV negative for viral DNA by PCR test
3 HPV positive for viral DNA by PCR test
4 HPV negative by ISH E6/E7 RNA test
5 HPV positive by ISH E6/E7 RNA test
6 HPV negative by RT-PCR E6/E7 RNA test
7 HPV positive by RT-PCR E6/E7 RNA test
8 HPV status reported in medical records as positive or negative but test type is unknown
9 Unknown if HPV test detecting viral DNA and or RNA was performed