Brain Molecular Markers

Notes

**Note 1:** This data item applies only to ICD-O-3 histology codes: 9400/3, 9401/3, 9440/3, 9450/3, 9451/3, 9471/3 and 9478/3. If a histology is not included in this list, assign, code 85. **Note 2:** Physician statement of histologic subtype can be used to code this data item. **Note 3:** Only one code is applicable for each tumor. * IDH mutation status distinguishes between clinically important subtypes within ICD-O-3 9400/3, Diffuse astrocytoma and 9401/3, Anaplastic astrocytoma. * IDH mutant and 1p/19q co-deletion distinguishes between clinically important subtypes within ICD-O-3 code 9450/3, Oligodendroglioma and 9451/3, Anaplastic Oligodendroglioma. * IDH-wildtype distinguishes clinically important subtypes within ICD-O-3 9400/3, Diffuse astrocytoma, 9401/3, Anaplastic astrocytoma and 9440/3, Glioblastoma, Epithelioid glioblastoma and Glioblastoma, NOS (note that the new ICD-O-3 code 9445/3 applies to Glioblastoma, IDH-mutant; information regarding this subtype is not collected using this data item). * SHH-activation and TP53-wildtype distinguishes between clinically important subtypes within ICD-O-3 histology code 9471/3, Medulloblastoma. * C19MC alteration status distinguishes a clinically important highly aggressive subtype within ICD-O-3 9478/3, Embryonal tumor with multilayered rosettes. ***Examples:*** 1. Biopsy of brain tumor, microscopic confirmation diagnosis: Diffuse Astrocytoma (9400/3). Additional testing done and IDH-mutant is identified. Code 01. 2. Biopsy of brain tumor, microscopic confirmation diagnosis: Anaplastic astrocytoma (9401/3). No further testing or results unknown. Code 99. 3. MRI of brain tumor, clinical diagnosis: glioblastoma. No further workup. Code 99. 4. Biopsy of brain tumor, microscopic confirmation diagnosis: Mixed glioma (9382/3). Code 85.

Default

88

NAACCR Item

NAACCR #3816

Metadata

SSDI
Code Description
01 Diffuse astrocytoma, IDH-mutant (9400/3)
02 Diffuse astrocytoma, IDH-wildtype (9400/3)
03 Anaplastic astrocytoma, IDH-mutant (9401/3)
04 Anaplastic astrocytoma, IDH-wildtype (9401/3)
05 Glioblastoma, IDH-wildtype (9440/3)
06 Oligodendroglioma, IDH-mutant and 1 p/19q co-deleted (9450/3)
07 Anaplastic oligodendroglioma, IDH-mutant and 1p/19q co-deleted (9451/3)
08 Medulloblastoma, SHH-activated and TP53-wildtype (9471/3)
09 Embryonal tumor with multilayered rosettes, C19MC-altered (9478/3)
85 Not applicable: Histology not 9400/3, 9401/3, 9440/3, 9450/3, 9451/3, 9471/3, 9478/3
86 Benign or borderline tumor
87 Test ordered, results not in chart
88 Not applicable: Information not collected for this case (If this item is required by your standard setter, use of code 88 will result in an edit error.)
99 Not documented in patient record No microscopic confirmation Brain molecular markers not assessed or unknown if assessed