Lymph Nodes Isolated Tumor Cells (ITC)


**Note 1:** Physician statement of Isolated Tumor Cells (ITCs) can be used to code this data item when no other information is available. **Note 2:** ITCs include single tumor cells or small clusters, less than or equal to 0.2 mm in greatest dimension, generally without stromal response in the lymph node. These cells usually are found in the subcapsular nodal sinuses but may be seen within the nodal parenchyma. **Note 3:** ITCs may be identified in lymph nodes by hematoxylin and eosin staining or by specialized pathological techniques, such as IHC for cytokeratin proteins for carcinomas. Specialized pathology techniques such IHC and molecular techniques are not recommended for routine examination of lymph nodes. **Note 4:** Record the status of ITCs as documented by the pathologist.




NAACCR #3880


Code Description
0 Regional lymph nodes negative for ITCs
1 Regional lymph nodes positive for ITCs (Tumor cell clusters not greater than 0.2 millimeter (mm))
8 Not applicable: Information not collected for this case (If this information is required by your standard setter, use of code 8 may result in an edit error.)
9 Not documented in patient record Cannot be determined by pathologist ITCs not assessed or unknown if assessed